Prognostic value of preoperative N-terminal pro-brain natriuretic peptide in non-cardiac surgery of elderly patients with normal left ventricular systolic function

Geriatrics & Gerontology International
In Jai KimDong-Hun Cha

Abstract

We investigated the prognostic value of preoperative N-terminal pro-brain natriuretic peptide (NT-proBNP) in non-cardiac surgery in elderly patients who showed normal left ventricular function on preoperative echocardiography. We analyzed 1459 patients aged older than 70 years who had consulted a cardiologist for the evaluation of cardiovascular risk for non-cardiac surgery. Of the 721 patients who simultaneously underwent echocardiography and NT-proBNP assessments, 506 who showed normal left ventricular systolic function were included. The predictive power of NT-proBNP for the risk of major adverse cardiac and cerebrovascular events (MACCE) was evaluated. MACCE occurred in 40 (7.9%) of the 506 patients, and the median value of NT-proBNP was higher in patients with complications than in those without (MACCE group: 1700.5 pg/mL vs non MACCE group: 206.35 pg/mL; P < 0.001). The area under the receiver operating characteristic curve was 0.804 (P < 0.001), with an optimal cut-off of 425.3 pg/mL. Multivariate analysis showed that increased NT-proBNP (>425.3 pg/mL; odds ratio 6.381; P < 0.001) was the only independent risk factor for the prediction of MACCE. In elderly patients who showed normal left ventricular systolic function on ...Continue Reading

References

May 15, 2002·Progress in Cardiovascular Diseases·Martin R Cowie, Gustavo F Mendez
May 28, 2003·The American Journal of Cardiology·Adam J Gordon, David S Macpherson
Nov 7, 2006·The American Journal of Geriatric Cardiology·Abu ShoyebRichard Steingart
Dec 22, 2007·European Journal of Heart Failure·Haïfa MahjoubChristophe Tribouilloy
Jan 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Kyeong Ho YunJin-Won Jeong
Jul 16, 2009·Anesthesiology·Alisdair D S RydingDavid Burgess
Jul 10, 2012·European Journal of Heart Failure·Luis ManzanoMarcus Flather

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