Abstract
Preoperative nutritional and immunological patient factors have been found to be associated with prognostic outcomes of malignant tumors; however, the clinical significance of these factors in pancreatic ductal adenocarcinoma (PDAC) remains controversial. The aim of this study was to evaluate the prognostic value of nutritional and immunological factors in predicting survival of patients with PDAC. Retrospective studies of 329 patients who underwent surgical resection for PDAC and 95 patients who underwent palliative surgery were separately conducted to investigate the prognostic impact of tumor-related factors and patient-related factors, including Glasgow Prognostic Score (GPS), modified GPS, Prognostic Nutritional Index (PNI), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio, and lymphocyte/monocyte ratio. In multivariate analysis for patients with surgical resection for PDAC, PNI was an independent factor for overall survival (OS) and disease-free survival. The median OS of patients with PNI ≤ 45 was significantly shorter than that of patients with PNI > 45 (17.5 and 36.2 months, respectively; p < 0.001). In multivariate analysis for patients undergoing palliative surgery for PDAC, only NLR was an independent pr...Continue Reading
References
Mar 1, 1996·Annals of Surgery·K C ConlonM F Brennan
Jul 4, 2002·Nutrition and Cancer·D C McMillanC S McArdle
Jul 27, 2004·Annals of Surgery·Murray F BrennanKevin Conlon
Aug 3, 2004·Nature Reviews. Immunology·Jukka Vakkila, Michael T Lotze
Oct 6, 2006·European Journal of Clinical Nutrition·B LakyA Obermair
Jan 25, 2007·International Journal of Colorectal Disease·Donald C McMillanColin S McArdle
Jun 25, 2009·Cancer Research·Isabelle Ray-CoquardUNKNOWN European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Apr 29, 2010·Surgery Today·Tadahiro NozoeTakahiro Ezaki
Oct 21, 2010·The British Journal of Surgery·M KandaA Nakao
Jan 27, 2011·Annals of Surgical Oncology·Nigel B JamiesonDonald C McMillan
Dec 6, 2011·Surgery Today·Tadahiro NozoeTakahiro Ezaki
Apr 6, 2012·Medical Oncology·De-shen WangRui-hua Xu
Apr 11, 2012·Annals of Surgical Oncology·Marco La TorreGiovanni Ramacciato
Mar 27, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa MartinVickie E Baracos
Jun 27, 2013·British Journal of Cancer·M StotzM Pichler
Aug 29, 2013·Annals of Surgical Oncology·Teiichi SugiuraYukiyasu Okamura
Nov 26, 2014·Pancreas·Qiwen BenYaozong Yuan
Mar 24, 2015·Surgery·Shinya OkumuraShinji Uemoto
Jun 3, 2015·Surgery·Yoshihiro ShiraiKatsuhiko Yanaga
Jun 17, 2016·Medicine·Mitsuro KandaYasuhiro Kodera
Oct 23, 2016·Annals of Surgical Oncology·Marek SierzegaJan Kulig
Dec 13, 2016·Surgery·Toshiya AbeMasafumi Nakamura
Dec 15, 2016·Nutrition and Cancer·Sang Hoon LeeJae Bock Chung
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Citations
Aug 9, 2020·Cancer Management and Research·He Song, Ming Dong
May 23, 2019·Frontiers in Oncology·Michal YalonRuty Mehrian-Shai
Sep 26, 2020·European Radiology·Yan-Chih PengBang-Bin Chen
Mar 29, 2020·PeerJ·Ankang WangYu Jiang
Mar 4, 2020·Surgery Today·Tatsuo HataMichiaki Unno
Aug 22, 2020·Dose-response : a Publication of International Hormesis Society·Wen FuTao Wu
Aug 13, 2020·BMC Cancer·David T PointerMokenge P Malafa
Mar 10, 2020·World Journal of Gastroenterology : WJG·Shuai-Shuai XuXian-Jun Yu
Jul 28, 2020·World Journal of Surgical Oncology·Shuwen LinZhixiang Jian
Sep 29, 2020·Cancer Cell International·Huan ZhangHeshui Wu
Oct 9, 2020·European Journal of Medical Research·Laura van WijkJoost M Klaase
Dec 4, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Xin LuoQing Zhai
Sep 27, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Tomoyuki AbeToshio Noriyuki
Feb 2, 2021·The American Surgeon·James S StrongAlice C Wei
Jan 12, 2021·Surgery·Shunsuke OnoeTomoki Ebata
Jan 7, 2021·Aging·Dongdong WuGuoxing Ge
Jun 18, 2021·Frontiers in Oncology·Haoran LiJian Zhou
Jul 8, 2021·International Journal of Clinical Oncology·Kyohei AbeToru Ikegami
Aug 25, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Shinji ItohMasaki Mori
Sep 26, 2020·Surgical Case Reports·Chikanori TsutsumiToru Nakano