Prognostic Value of Preoperative Nutritional and Immunological Factors in Patients with Pancreatic Ductal Adenocarcinoma

Annals of Surgical Oncology
Toshiya AbeMasafumi Nakamura

Abstract

Preoperative nutritional and immunological patient factors have been found to be associated with prognostic outcomes of malignant tumors; however, the clinical significance of these factors in pancreatic ductal adenocarcinoma (PDAC) remains controversial. The aim of this study was to evaluate the prognostic value of nutritional and immunological factors in predicting survival of patients with PDAC. Retrospective studies of 329 patients who underwent surgical resection for PDAC and 95 patients who underwent palliative surgery were separately conducted to investigate the prognostic impact of tumor-related factors and patient-related factors, including Glasgow Prognostic Score (GPS), modified GPS, Prognostic Nutritional Index (PNI), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio, and lymphocyte/monocyte ratio. In multivariate analysis for patients with surgical resection for PDAC, PNI was an independent factor for overall survival (OS) and disease-free survival. The median OS of patients with PNI ≤ 45 was significantly shorter than that of patients with PNI > 45 (17.5 and 36.2 months, respectively; p < 0.001). In multivariate analysis for patients undergoing palliative surgery for PDAC, only NLR was an independent pr...Continue Reading

References

Jul 27, 2004·Annals of Surgery·Murray F BrennanKevin Conlon
Aug 3, 2004·Nature Reviews. Immunology·Jukka Vakkila, Michael T Lotze
Oct 6, 2006·European Journal of Clinical Nutrition·B LakyA Obermair
Jan 25, 2007·International Journal of Colorectal Disease·Donald C McMillanColin S McArdle
Jun 25, 2009·Cancer Research·Isabelle Ray-CoquardUNKNOWN European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Oct 21, 2010·The British Journal of Surgery·M KandaA Nakao
Mar 27, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa MartinVickie E Baracos
Dec 15, 2016·Nutrition and Cancer·Sang Hoon LeeJae Bock Chung
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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Citations

May 23, 2019·Frontiers in Oncology·Michal YalonRuty Mehrian-Shai
Aug 22, 2020·Dose-response : a Publication of International Hormesis Society·Wen FuTao Wu
Mar 10, 2020·World Journal of Gastroenterology : WJG·Shuai-Shuai XuXian-Jun Yu
Sep 27, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Tomoyuki AbeToshio Noriyuki
Jul 8, 2021·International Journal of Clinical Oncology·Kyohei AbeToru Ikegami
Aug 25, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Shinji ItohMasaki Mori

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