Prognostic Value of Preoperative Systemic Immunoinflammatory Measures in Patients with Esophageal Cancer

Annals of Surgical Oncology
Yusuke IshibashiHideki Ueno

Abstract

It is reported that several systemic immunoinflammatory measures, including systemic immune-inflammatory index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, and C-reactive protein (CRP)-to-albumin ratio (CAR), are associated with survival in patients with various types of cancer. The aim of the present study was to clear which systemic immunoinflammatory measures had the greatest prognostic values. In addition, we examined which component had the greatest prognostic power in patients with esophageal cancer. Preoperative systemic immunoinflammatory measures were evaluated in 143 patients undergoing esophageal resection for esophageal cancer from 2009 to 2014. Univariate and multivariate analyses were performed to determine the prognostic significance of these markers. Receiver operating characteristic (ROC) curves were plotted, and the area under the ROC curves (AUROCs) were compared to verify the accuracy of each measure in predicting overall survival (OS). In univariate analysis, preoperative SII, NLR, and CAR were the predictors of OS in patients who underwent esophagectomy for esophageal cancer (p < 0.05, respectively), whereas in multivariate analysis, CAR and pathological tumor depth were the s...Continue Reading

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Citations

Feb 6, 2020·Annals of Gastroenterological Surgery·Yusuke IshibashiHideki Ueno
May 26, 2020·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Sivesh K KamarajahEwen A Griffiths
Mar 25, 2019·Oncoimmunology·Pranav MurthyMichael T Lotze
Oct 10, 2018·Annals of Surgical Oncology·Yusuke Ishibashi, Hironori Tsujimoto
Sep 9, 2020·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Yingjia WuMian Xi

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