Prognostic Value of Pretreatment FDG-PET Parameters in High-dose Image-guided Radiotherapy for Oligometastatic Non-Small-cell Lung Cancer

Clinical Lung Cancer
Alexander L ChinMichael F Gensheimer

Abstract

Emerging data support aggressive local treatment of oligometastatic non-small-cell lung cancer (NSCLC) patients. We sought to determine whether the metabolic burden of disease found by fluorodeoxyglucose positron emission tomography at the time of high-dose radiotherapy (RT) for oligometastatic NSCLC can serve as a prognostic biomarker. We conducted a retrospective cohort study of 67 RT treatment courses in 55 patients with oligometastatic NSCLC who had undergone high-dose RT to all sites of active disease at our institution. The metabolic tumor volume, total lesion glycolysis (TLG), and maximum standardized uptake value of all lesions were measured on the pretreatment fluorodeoxyglucose positron emission tomography scans. Cox regression analysis was used to assess the influence of imaging and clinical factors on overall survival (OS). On univariate analysis, a greater metabolic tumor volume and TLG were predictive of shorter OS (hazard ratio of death, 2.42 and 2.14, respectively; P = .009 and P = .004, respectively). The effects remained significant on multivariate analysis. Neither the maximum standardized uptake value nor the number of lesions was significantly associated with OS. Patients within the highest quartile of TLG ...Continue Reading

Citations

Nov 23, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Romain-David SebanBenjamin Besse
May 31, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephen R BowenJing Zeng
Mar 25, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Chukwuka EzeMarcus Unterrainer
Apr 24, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Filippo G Dall'OlioAndrea Ardizzoni
Jun 7, 2021·Seminars in Radiation Oncology·Xingzhe LiPuneeth Iyengar

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