Prognostic value of pretreatment inflammatory biomarkers in primary small cell carcinoma of the esophagus

Thoracic Cancer
Nan WangHong Ge

Abstract

Growing evidence indicates that several inflammatory biomarkers may predict survival in patients with malignant tumors. The aim of this study was to evaluate the prognostic value of pretreatment biomarkers in patients with primary small-cell carcinoma of the esophagus (PSCCE). A total of 73 PSCCE patients enrolled between January 2009 and December 2017 at the Affiliated Cancer Hospital of Zhengzhou University. The total lymphocyte counts (TLC), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) prior to anticancer therapy were collected as inflammation biomarkers. The cutoff value was determined by Receiver operating characteristic (ROC). The Kaplan-Meier method was utilized to analyze overall survival (OS). Cox proportional hazards regression was used to identify univariate and multivariate prognostic factors. Univariate analysis showed that high NLR group (hazard ratio [HR] = 1.685; 95% CI: 1.001-2.838; P = 0.047) and high PLR group (hazard ratio [HR] = 1.716; 95% CI: 1.039-2.834; P = 0.033) were associated with poor OS, and TLC was not correlated with OS. On multivariate analysis, high PLR (hazard ratio [HR] = 1.751; 95% CI: 1.042-2.945; P = 0.035) was an independent prognostic factor of unfavorable ...Continue Reading

References

Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Oct 1, 1952·The Journal of Pathology and Bacteriology·F MCKEOWN
Nov 10, 2004·World Journal of Gastroenterology : WJG·Zhu WuShang-Fu Zhang
Jan 11, 2007·The Journal of Cell Biology·Tobias A FuchsArturo Zychlinsky
Oct 20, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G Y KuD H Ilson
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Aug 15, 2008·Cytokine·Giovanni GermanoAlberto Mantovani
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Nov 3, 2010·Journal of Thrombosis and Haemostasis : JTH·N M Bambace, C E Holmes
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 16, 2012·Nature Reviews. Cancer·Wolf Herman FridmanJérôme Galon
Nov 20, 2012·Oncoimmunology·Jacques ThibodeauRéjean Lapointe
May 4, 2013·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Y ZhuM Liu
Jan 21, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Krasimira AleksandrovaTobias Pischon
Jul 19, 2014·International Journal of Radiation Oncology, Biology, Physics·Chad TangJames W Welsh
Nov 21, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·X XieJ Chen
Oct 21, 2015·Journal of the National Comprehensive Cancer Network : JNCCN·Stuart A GrossmanXiaobu Ye
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Oct 13, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Lei XuXiankai Chen
Feb 6, 2018·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ryoko SuzukiRitsuko Komaki
Mar 29, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Lulu YeHongmei Ying

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
surgical resection

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.