Prognostic value of programed death ligand 1 in patients with solid tumors: A meta-analysis

Journal of Cancer Research and Therapeutics
Ying JinXinmin Yu

Abstract

A great deal of research have been performed to explore the prognostic value of programed death ligand 1 (PD-L1) in solid tumors in last decades. However, the results still remain inconsistent. To clarify a precise determinant of the clinical significance of PD-L1, we conducted a meta-analysis to evaluate the overall risk of PD-L1 on survival for patients with solid tumors. Related studies were identified through multiple search strategies from PubMed, Embase, and Cochrane databases. Data were collected from studies comparing overall survival (OS) in patients with positive PD-L1 and those having a negative expression. The meta-analysis was performed by Stata version 11.0 (Stata Corporation, College Station, TX, USA). The pooled hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated employing fixed- or random-effects models depending on the heterogeneity of the included trials. A total of 14 eligible studies involved 2916 patients were included in our meta-analysis. A summary HRs of all studies and subgroup HRs were calculated. The combined HRs suggested that a positive PD-L1 expression had an unfavorable impact on OS (1.67, 95% CI 1.30-2.16; P < 0.001). Similar results were also observed in subgroup analysis...Continue Reading

Citations

Mar 4, 2019·Frontiers of Medicine·Yumeng Wang, Guiling Li
Jan 5, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Julius StraussJames L Gulley

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