Prognostic Value of Programmed Cell Death 1 Ligand-1 (PD-L1) or PD-1 Expression in Patients with Osteosarcoma: A Meta-Analysis

Journal of Cancer
Xin HuangZengwu Shao

Abstract

Purpose: Programmed cell death 1 ligand-1 (PD-L1) and PD-1 as prognostic biomarkers have spurred considerable interest in several types of malignant tumors. In the present meta-analysis, we aimed to elucidate the clinicopathological and prognostic values of PD-L1/PD-1 in osteosarcoma. Methods: We systematically searched PubMed, Web of Science, EMBASE, Scopus, CBM and the Cochrane Library databases up to March 3, 2018. Eligible studies assessing the relationship between PD-L1 or PD-1 expression and clinicopathological and prognostic outcomes in osteosarcoma were incorporated. Pooled relative risks (RRs) and 95% confidence intervals (CIs) were used to estimate the outcomes. Results: Eight studies involving 413 patients were incorporated into our meta-analysis. Pooled results showed that PD-L1/PD-1 overexpression was significantly associated with metastasis (RR = 1.54, 95% CI: 1.12-2.11, p = 0.008) in osteosarcoma. Furthermore, osteosarcoma patients exhibited a remarkably higher total mortality risk (RR = 1.86, 95% CI: 1.09-3.17, p = 0.021) with PD-L1/PD-1 overexpression. However, no significant reduced overall survival rate (RR = 0.70, 95% CI: 0.46-1.07, p = 0.103) was detected in the study. Conclusion: Our meta-analysis indicate...Continue Reading

Citations

Jan 10, 2019·International Journal of Molecular Sciences·Shinji MiwaHiroyuki Tsuchiya
Jan 4, 2020·Journal of Cellular Biochemistry·Jun ZhangZhiwei Liu
May 31, 2019·Cancer Cell International·Xiaobin GuYonggang Shi
Aug 6, 2020·Diagnostics·Kazuhiko HashimotoMasao Akagi
Jan 11, 2019·Bulletin of Experimental Biology and Medicine·N E KushlinskiiI A Kazantseva
Jun 4, 2019·Frontiers in Immunology·Zenan WangZhaoming Ye
Dec 19, 2019·Frontiers in Oncology·Francesca PerutNicola Baldini
Jul 14, 2020·Seminars in Cancer Biology·Ombretta MelaiuFederica Gemignani
Dec 12, 2020·Journal of Hematology & Oncology·Jeong A Park, Nai-Kong V Cheung
Jan 21, 2021·Cells·Alannah SmrkeRobin L Jones

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