PMID: 8608356Dec 1, 1995Paper

Prognostic value of quantitative measurement of rheumatoid factor in early rheumatoid arthritis

British Journal of Rheumatology
L PaimelaK Aho

Abstract

The prognostic value of quantitative measurement of rheumatoid factor (RF) by immunoturbidimetry was evaluated in 78 patients with early rheumatoid arthritis (RA) during a 3-yr follow-up. After starting disease-modifying antirheumatic treatment, a significant improvement in conventional clinical and laboratory variables measuring disease activity was observed, while a steady increase was found in radiological progression. Initial RF levels correlated with radiologically determined joint damage up to 3 yr, whereas no correlation of other initially determined conventional variables of disease activity was found. High levels of RF at entry and persistent RF positivity during the follow-up were markers for destructive disease. Initial RF positivity alone was a sensitive predictor for later joint destruction, but quantitative measurement of the initial RF level and especially repeated measurements of RF seemed to add significantly to the prognostic value of RF in distinguishing between progressive and non-progressive disease in early RA.

Citations

Feb 5, 1999·Clinical and Experimental Immunology·N MillauerB M Stadler
Dec 15, 2000·Annals of the Rheumatic Diseases·L PaimelaR von Essen
Jan 29, 2011·Current Medical Research and Opinion·Iris GoetzKimberly L Sterling
Apr 5, 2002·Arthritis and Rheumatism·Carlos H OrcesAgustín Escalante
Feb 8, 2006·Seminars in Arthritis and Rheumatism·Dinesh KhannaCatherine H MacLean
May 19, 2001·Best Practice & Research. Clinical Rheumatology·J R O'Dell
Aug 13, 2005·Scandinavian Journal of Rheumatology·S Rantapää-Dahlqvist
Feb 1, 2000·Baillière's Best Practice & Research. Clinical Rheumatology·P G ConaghanP Emery
Dec 14, 2004·Best Practice & Research. Clinical Rheumatology·J Morel, B Combe
Dec 16, 2003·Arthritis and Rheumatism·Patrik WernhoffRikard Holmdahl
Aug 2, 2001·Internal Medicine Journal·A A Williamson, G J McColl
Oct 18, 2019·Antioxidants·Heloisa V Pereira-MarósticaAnacharis B Sá-Nakanishi
Mar 3, 1998·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·L F CallahanJ J Kaye

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