Prognostic value of right ventricular longitudinal strain in patients with pulmonary hypertension: a systematic review and meta-analysis

European Heart Journal Cardiovascular Imaging
Hugo G HulshofDick H J Thijssen

Abstract

Pulmonary hypertension (PH) is associated with high morbidity and mortality and the predictive capacity of traditional functional echocardiographic measures is poor. Recent studies assessed the predictive capacity of right ventricular longitudinal strain (RVLS). Diversity in methods between these studies resulted in conflicting outcomes. The purpose of this systematic review and meta-analysis was to determine the independent prognostic value of RVLS for PH-related events and all-cause mortality. A systematic search in Pubmed (MEDLINE), Embase, the Cochrane Library, and Web of Science was performed to identify studies that examined the prognostic value of RVLS in patients with PH. Studies reporting Cox regression based hazard ratios (HRs) for a combined endpoint of mortality and PH-related events or all-cause mortality for echocardiographic derived RVLS were included. A weighted mean of the multivariate HR was used to determine the independent predictive value of RVLS. Eleven studies met our criteria, including 1169 patients with PH (67% female, 0.6-3.8 years follow-up). PH patients with a relative reduction of RVLS of 19% had a significantly higher risk for the combined endpoint [HR 1.22, 95% confidence interval (CI) 1.07-1.40]...Continue Reading

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Citations

Feb 26, 2019·Nature Machine Intelligence·Ghalib A BelloDeclan P O'Regan
Jul 8, 2020·European Heart Journal Cardiovascular Imaging·Hugo G HulshofDick H J Thijssen
Aug 5, 2020·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Davide StolfoGianfranco Sinagra
Jun 4, 2021·Journal of Cardiovascular Imaging·Omar PrietoJuan Alberto Gagliardi
Jun 4, 2021·Journal of Cardiovascular Imaging·Hyung Yoon Kim, Kye Hun Kim
Jul 3, 2021·Journal of Clinical Medicine·Ioannis T FarmakisGeorge Giannakoulas
Nov 19, 2021·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Marius KellerHarry Magunia
Jan 29, 2022·Journal of Medical Ultrasonics·Toshimitsu KatoMasaru Obokata

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