Abstract
The nucleotide degrading enzyme gene RNASEH2A (ribonuclease H2 subunit A) has been found to be overexpressed in cancers. Our aim was to understand the role of RNASEH2A in cancer prognostication and to establish a scoring system based on the expressions of genes interacting with RNASEH2A. We screened the nucleotide degrading enzyme gene expression in RNAseq data of 14 cancer types derived from The Cancer Genome Atlas (TCGA) and found that RNASEH2A overexpression was associated with poor patient survival only in renal cell carcinomas (RCCs). Further cluster analyses of samples with poor outcomes revealed that cluster of differentiation 151 (CD151) upregulation correlated with low cyclin dependent kinase 1 (CDK1) and high RNASEH2A expression. The combination of low CD151 expression and high RNASEH2A expression resulted in impaired proliferation in four kidney cancer cell lines, suggesting potential synthetic dosage lethality (SDL) interactions between the two genes. A prognostication scoring system was established based on the expression levels of RNASEH2A-, CDK1-, and CD151-related genes, which could effectively predict the overall survival in a TCGA clear cell RCC cohort (n = 533, 995.3 versus 2242.2 days, p < 0.0001), in anothe...Continue Reading
References
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert J MotzerMadhu Mazumdar
Apr 25, 2009·International Journal of Cancer. Journal International Du Cancer·Daniela WuttigManfred P Wirth
Feb 18, 2011·Histopathology·Seong H YooKyung C Moon
Aug 7, 2012·Molecular Cell·Justin L SparksPeter M Burgers
Dec 20, 2012·PloS One·Jan BudcziesCarsten Denkert
Nov 20, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Rafal SadejHanna M Romanska
Mar 7, 2014·Seminars in Interventional Radiology·Carole A RidgeDavid C Madoff
Apr 22, 2014·Nature Immunology·Hannah E Volkman, Daniel B Stetson
Sep 15, 2014·Cancer Letters·Seung Jin KimShinzaburo Noguchi
Nov 21, 2014·PLoS Genetics·Kendra A WilliamsNigel P S Crawford
Dec 3, 2014·Urologic Oncology·Fumiya HongoTsuneharu Miki
Jan 31, 2015·Nature Reviews. Drug Discovery·Uzma AsgharErik S Knudsen
Apr 26, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qinghua XiShuyun Yang
Sep 16, 2015·Proceedings of the National Academy of Sciences of the United States of America·Wout MegchelenbrinkRichard A Notebaart
Sep 30, 2015·Molecular Cancer·Rebecca KohnkenLi Wu
Nov 26, 2015·Progress in Biophysics and Molecular Biology·Shaolong Feng, Zhaohui Cao
Feb 18, 2016·The Journal of Experimental Medicine·Vladislav PokatayevRobert J Crouch
Apr 7, 2016·JAAD Case Reports·Miesha MeratiMeg R Gerstenblith
Nov 20, 2016·Oncotarget·Eva JuengelRoman A Blaheta
Dec 8, 2016·Nucleic Acids Research·Damian SzklarczykChristian von Mering
Dec 19, 2016·Oncology·Chin-An YangJan-Gowth Chang
Jun 28, 2017·PloS One·Sung Han KimJinsoo Chung
Oct 27, 2017·Oncotarget·Wei GanJiangsheng Huang
Nov 4, 2017·International Journal of Molecular Sciences·Karthik V GiridharManish Kohli
Citations
Nov 13, 2020·BioMed Research International·Yu SunMao-Lin He
May 18, 2021·Frontiers in Oncology·Florent PetitprezSylvie Job
Jun 29, 2021·Frontiers in Genetics·Guo-Jiang ZhaoLulin Ma
Jul 14, 2021·Environmental Toxicology·Jing ZhangMengxiang Yang