Prognostic Value of Serial Echocardiography in Hypoplastic Left Heart Syndrome

Circulation. Cardiovascular Imaging
Jae Sung SonMark K Friedberg

Abstract

Hypoplastic left heart syndrome (HLHS) carries a high mortality. The prognostic value of echocardiographic variables at presentation and the importance of serial data are poorly explored. We retrospectively analyzed longitudinal clinical and echocardiographic parameters of children with hypoplastic left heart syndrome. The primary outcome was time to death or transplant after stage-1 surgery, right censored at stage 3 surgery, accounting for sequential surgical procedures. Univariable and multivariable analysis identified risk factors for transplant or mortality. Time-dependent trends in echo parameters stratified by patient survival were explored using nonparametric methods. In total 67 children with hypoplastic left heart syndrome were included. The 10-week, 20-week, and 1-year survival proportions were 77.6% (66-86), 68.7% (56-78), and 54.1% (41-65), respectively. At presentation, multivariable analysis identified a thicker interventricular septum (hazard ratio [HR], 1.64; P=0.007) to be associated with increased risk for transplant/death, whereas higher tricuspid valve annular planar systolic excursion z score (HR, 0.61; P=0.003) was associated with reduced risk of mortality/transplant. After stage-1, higher body surface ar...Continue Reading

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Citations

Jul 18, 2018·Circulation. Cardiovascular Imaging·Laura Mercer-Rosa, David J Goldberg
Jul 30, 2019·Current Opinion in Pediatrics·Mark K Friedberg, Sushma Reddy
Oct 27, 2020·Pediatric Cardiology·Alan P WangUNKNOWN Wanek Family Program for Hypoplastic Left Heart Syndrome Imaging Pipeline
Nov 27, 2020·Stem Cell Research & Therapy·Christoph HallerMichael A Laflamme
Feb 19, 2021·Seminars in Thoracic and Cardiovascular Surgery·Mohamed Abdullah, Sunjay Kaushal
Mar 24, 2021·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Ling LiShelby Kutty
May 15, 2021·Pediatric Cardiology·Sowmya BalasubramanianRajesh Punn
May 30, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Mohamed SobhInga Voges

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