Prognostic value of serum selenium levels in alcoholics

Biological Trace Element Research
E González-ReimersM Candelaria Martín-González

Abstract

In alcoholics, exposure of Kupffer cells to intestinal-borne Gram-negative bacteria increases free radical release, which may, in turn, enhance cytokine secretion, creating a positive feedback loop, which contributes to liver inflammation. Impaired antioxidant mechanisms further aggravates this scenario. Some trace elements, such as selenium, are main cofactors of antioxidant enzymes. Some authors have found low Se levels in alcoholics in relation either with undernutrition, liver dysfunction, or intensity of alcoholism, but in general, Se supplementation has no effect on survival. In this study we measured serum Se in 16 controls and 76 alcoholics, 34 of them cirrhotics, 68 of whom were followed up for a median period of 38 months; 17 died during this period. Se levels were lower in patients than in controls and were related to prothrombin activity and nutritional status, more closely to this last parameter (stepwise logistic regression analysis). Patients who died showed lower Se values than those who survived. Se values over the median were associated with better survival, assessed by Kaplan-Meier curves and log-rank test. However, in multivariate analysis (Cox regression model), prothrombin activity displaced serum Se as a ...Continue Reading

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Citations

Jul 4, 2013·Biological Trace Element Research·E González-ReimersF Santolaria-Fernández
Sep 28, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Emilio González-ReimersFrancisco Santolaria-Fernández
Mar 9, 2012·Forschende Komplementärmedizin = Research in Complementary Medicine·Dirk-Henrik Zermann
Jan 1, 2012·Microbial Ecology in Health and Disease·Olav Albert Christophersen
Oct 28, 2010·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·María L OjedaOlimpia Carreras
May 16, 2009·Biological Trace Element Research·Emilio González-ReimersFrancisco Santolaria-Fernández
Mar 11, 2015·Journal of Clinical and Experimental Hepatology·Swastik Agrawal, Radha K Dhiman
Mar 11, 2015·Journal of Clinical and Experimental Hepatology·Chantal Bémeur, Roger F Butterworth
Mar 8, 2011·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·José María González-PérezPedro Abreu-González
Sep 21, 2010·Nutrition Research·Manuel Martínez-PeinadoMiguel Navarro-Alarcón
Jun 5, 2015·Journal of Clinical and Experimental Hepatology·Chantal Bémeur, Roger F Butterworth
Nov 5, 2013·Metallomics : Integrated Biometal Science·Marco RomanCarlo Barbante
Mar 12, 2021·Frontiers in Nutrition·Yuki IsobeToshinari Takamura

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