Prognostic value of serum soluble FMS-like tyrosine kinase (sFlt-1) levels in pre-eclampsia and eclampsia; a prospective cohort study

Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy
Ahmed M AbbasMona A H El-Baz

Abstract

To evaluate the levels of circulating sFlt-1 in pre-eclampsia (PE) and eclampsia patients and to assess its prognostic value in detection of PE complications. The present study was a prospective cohort study conducted in tertiary hospital between January and December 2016. Included patients were divided into two groups; (Group I) severe PE group and (Group II) eclampsia group. Age-, parity-, and gestational age-matched women had approached to participate in the study as a control group (Group III). Serum sFlt-1 levels were measured at inclusion and 2 days later with all basic investigations. Patients were followed up until delivery to record any complications. Correlation analysis was performed between the serum sFlt-1 levels and clinical, laboratory investigations. Receiver operating characteristic analysis was constructed for the evaluation of the area under curve (AUC) as well as the sensitivity and specificity regarding the cutoff point of sFlt-1 level that predict occurrence of complications. The study included 84 women. Women with complicated severe PE showed higher sFlt-1 levels than in non-complicated cases (120.2 ± 19.6 versus 72.2 ± 19.6, p < 0.001). Similarly, the mean serum level of sFlt-1 in complicated eclampsia w...Continue Reading

References

Feb 7, 2004·The New England Journal of Medicine·Richard J LevineS Ananth Karumanchi
Jun 11, 2005·Science·Christopher W Redman, Ian L Sargent
Sep 8, 2006·The New England Journal of Medicine·Richard J LevineUNKNOWN CPEP Study Group
Dec 11, 2007·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·J MenziesP von Dadelszen
Oct 21, 2009·Journal of Cellular and Molecular Medicine·Florence T H WuAleksander S Popel
Nov 11, 2010·American Journal of Obstetrics and Gynecology·Edi VaisbuchS Ananth Karumanchi
Mar 2, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Shakila ThangaratinamUNKNOWN TIPPS (Tests in Prediction of Pre-eclampsia's Severity) Review Group
Jul 16, 2011·British Journal of Anaesthesia·J H McClureUNKNOWN Centre for Maternal and Child Enquiries
Aug 11, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tinnakorn ChaiworapongsaSonia S Hassan
Feb 4, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sophia MasouraTheodoros Agorastos
Aug 12, 2014·The Lancet Global Health·Lale SayLeontine Alkema
Jan 21, 2015·Journal of the American Society of Hypertension : JASH·Louise Bjørkholt AndersenHenrik Thybo Christesen
Jan 31, 2015·Current Opinion in Nephrology and Hypertension·Monica SircarS Ananth Karumanchi
Jan 7, 2016·The New England Journal of Medicine·Harald ZeislerStefan Verlohren
Mar 31, 2016·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·H StepanS Verlohren
Sep 7, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Grigorios A KarampasDemetrios A Rizos
Nov 12, 2016·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Ping TangQi-Mei Wang

❮ Previous
Next ❯

Citations

Mar 7, 2020·Archives of Gynecology and Obstetrics·Ye Sul ParkHai-Joong Kim
Sep 28, 2020·American Journal of Obstetrics and Gynecology·Michal Fishel Bartal, Baha M Sibai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved