Prognostic value of serum thioredoxin concentrations after intracerebral hemorrhage

Clinica Chimica Acta; International Journal of Clinical Chemistry
Song-Quan QianGuang-Hua Pan

Abstract

Thioredoxin (TRX) is a potent anti-oxidant and its circulating concentration is increased in some critical illnesses. We measured the serum TRX concentrations and further investigated the relationship between serum TRX concentrations and hemorrhagic severity and outcome after intracerebral hemorrhage (ICH). A total of 218 ICH patients and 218 healthy controls were enrolled in this prospective, observatory study. Serum TRX concentrations were determined using an enzyme-linked immunosorbent assay. Hemorrhagic severity was assessed with National Institutes of Health Stroke Scale (NIHSS) score and hematoma volume. Clinical endpoint was 6-month mortality. Compared with the controls, the patients had elevation of serum TRX concentrations (24.4±11.5 ng/ml vs. 8.4±3.3 ng/ml, P<0.001). Serum TRX concentrations were highly related to NIHSS score (r=0.532, P<0.001) and hematoma volume (r=0.486, P<0.001). Serum TRX concentrations higher than 29.6 ng/ml was an independent predictor of 6-month mortality (odds ratio, 3.978; 95% confidence interval, 1.486-10.649) and 6-month overall survival (hazard ratio, 3.511; 95% confidence interval, 1.827-6.746). TRX concentrations improved the predictive value of NIHSS score and hematoma volume for 6-mon...Continue Reading

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Citations

Mar 24, 2016·Journal of the Neurological Sciences·Jun-Xia DaiHua-Jun Ba
Jan 24, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Zhe-Ming XuChang Tao
Aug 23, 2017·Neurological Research·Tieer YuBei Shao
Nov 24, 2017·Free Radical Research·Cezary GrochowskiRyszard Maciejewski
Jan 15, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Takahiko ImaiHideaki Hara
Mar 11, 2021·Oxidative Medicine and Cellular Longevity·Zhenjia YaoGaiqing Wang

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