Prognostic value of serum uric acid in patients with acute heart failure: A meta-analysis

Medicine
Gang HuangLei Wang

Abstract

Conflicting results have been reported on the prognostic significance of serum uric acid (SUA) in patients with acute heart failure (AHF). This meta-analysis aimed to determine the prognostic significance of SUA level in patients with AHF. We made a comprehensive literature search in Pubmed and Embase databases from inception to April 6, 2018. All available observational studies or post hoc analysis of randomized controlled trial that evaluated the prognostic value of SUA level in patients with AHF were eligible. Outcome of interests were all-cause mortality and the combined endpoint of death or readmission. Prognostic values of SUA level were summarized as higher vs lower SUA category or per 1 mg/ml SUA rise. Ten studies involving 12,854 AHF patients were identified and analyzed. AHF patients with the highest SUA level had an increased risk of all-cause mortality (risk ratio [RR] 1.43; 95% confidence intervals [CI] 1.31-1.56) and combined endpoint of death or readmission (RR 1.68; 95% CI 1.33-2.13) after adjusting potential variables. In addition, per 1 mg/ml SUA rise significantly increased by 11% and 12% higher risk all-cause mortality and combined endpoint of death or readmission, respectively. A leave out 1 study sensitivi...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Sep 16, 2006·BMJ : British Medical Journal·Joseph LauIngram Olkin
Oct 27, 2006·European Journal of Heart Failure·Domingo A Pascual-FigalMariano Valdes
Jun 14, 2008·Journal of the American College of Cardiology·Joshua M HareUNKNOWN OPT-CHF Investigators
Oct 24, 2008·The New England Journal of Medicine·Daniel I FeigRichard J Johnson
Feb 25, 2009·European Journal of Internal Medicine·Anna L AlimondaAngel Llácer
Jan 29, 2011·Congestive Heart Failure·Leonardo TamarizJoshua Hare
Oct 20, 2011·JAMA : the Journal of the American Medical Association·Jersey ChenHarlan M Krumholz
May 16, 2012·Heart Failure Reviews·Marc Kaufman, Maya Guglin
Aug 13, 2013·European Journal of Heart Failure·He HuangJi Wang
Sep 1, 2015·International Journal of Cardiology·Wolfram DoehnerStefan D Anker
Sep 16, 2015·Nature Reviews. Cardiology·Robert J Mentz, Christopher M O'Connor
Nov 26, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Wei-Ming HuangChen-Huan Chen
Oct 19, 2016·Journal of cardiology·Hirotake OkazakiWataru Shimizu
Aug 16, 2017·The American Journal of Cardiology·Alberto PalazzuoliPeter A McCullough
Mar 5, 2018·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S CoiroG Ambrosio
Jun 10, 2018·Medicina clínica·Lluís LlaugerÒscar Miró
Jul 11, 2018·Current Heart Failure Reports·Agata Bielecka-DabrowaStephan von Haehling

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Citations

Jun 12, 2019·Heart Failure Reviews·Michael SarheneFan Guanwei
Jun 12, 2021·Expert Review of Cardiovascular Therapy·Asma GulabJanani Rangaswami
Jun 25, 2021·Frontiers in Cardiovascular Medicine·Yahong LiZhengfeng Xu
Jul 13, 2021·Cardiology Clinics·Davide AgnolettiClaudio Borghi

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