Prognostic value of six-minute walk distance at a South American pulmonary hypertension referral center

Pulmonary Circulation
Gabriela O S CostaJaquelina S Ota-Arakaki

Abstract

Six-minute walk distance (6MWD) assessment is recommended for pulmonary arterial hypertension multidimensional risk stratification. However, current 6MWD cut-off values were mainly derived from North American and European pulmonary arterial hypertension registries. Therefore, it is unknown if such cut-off values broadly apply to other geographical populations. In this study, we aimed to identify 6MWD cut-off values for Brazilian pulmonary arterial hypertension patients and to contrast our findings to current international Pulmonary Hypertension guidelines recommendations. One-hundred four consecutive pulmonary arterial hypertension patients were allocated in groups according to their 6MWD, considering 50 m as a clinically relevant 6MWD difference. Next, patients were categorized into different 6MWD ranges based on similar survival rates in each group: < 250 m, 250-400 m, and >400 m. The study outcome was all-cause mortality and transplantation according to the 6MWD range. Survival was truncated at five years. Median follow-up period was 4.35 years (0.48-5.00). Survival rates at 1, 2, 3, and 5 years were 96%, 89%, 81%, and 73%, respectively. Cox analyses adjusted for age, sex, and pulmonary arterial hypertension etiology showed ...Continue Reading

References

Jan 9, 1997·The New England Journal of Medicine·L J Rubin
Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·UNKNOWN ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories
Sep 3, 2002·Journal of the American College of Cardiology·Olivier SitbonGérald Simonneau
Jun 15, 2004·Journal of the American College of Cardiology·Robyn J BarstSean Gaine
Feb 4, 2006·American Journal of Respiratory and Critical Care Medicine·Marc HumbertGérald Simonneau
Jul 26, 2006·Heart & Lung : the Journal of Critical Care·Claiborne Miller-DavisNancy Kline Leidy
Oct 6, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A M IwamaV Z Dourado
Jun 8, 2010·The European Respiratory Journal·C CasanovaUNKNOWN Six Minute Walk Distance Project (ALAT)
Nov 2, 2011·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Maria Raquel Soaresa, Carlos Alberto de Castro Pereira
Mar 1, 2012·The European Respiratory Journal·Pilar Escribano-SubiasUNKNOWN REHAP investigators
Nov 21, 2012·International Journal of Cardiology·Marius M HoeperDavid Pittrow
Jun 22, 2013·European Journal of Preventive Cardiology·Eloara V M FerreiraJ Alberto Neder
Nov 26, 2013·Brazilian Journal of Physical Therapy·Raquel R BrittoVeronica F Parreira
Oct 15, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Harrison W FarberRaymond L Benza
May 6, 2016·Scandinavian Cardiovascular Journal : SCJ·Göran RådegranUNKNOWN Stefan Söderberg j , on behalf of SveFPH and SPAHR
Aug 5, 2017·The European Respiratory Journal·Athénaïs BouclyOlivier Sitbon
Jan 26, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Thomas A ZelnikerLutz Frankenstein
Dec 14, 2018·The European Respiratory Journal·Anton Vonk NoordegraafRobert Naeije

❮ Previous
Next ❯

Citations

Apr 16, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Simon MalenfantSteeve Provencher

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Harrison W FarberRaymond L Benza
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Elizabeth J CareyDavid D Douglas
© 2022 Meta ULC. All rights reserved