PMID: 11918533Mar 29, 2002Paper

Prognostic value of soluble interleukin 2 receptor levels in Langerhans cell histiocytosis

British Journal of Haematology
Diego Alfredo RossoJorge Braier

Abstract

We investigated the prognostic significance of soluble interleukin 2 receptor (sIL-2r) levels in the pre- and post-treatment serum of paediatric patients with Langerhans cell histiocytosis (LCH). Serum levels of sIL-2r from 32 LCH patients and 14 healthy controls were determined using enzyme-linked immunosorbent assay. The LCH patients were classified, evaluated and treated according to the Histiocyte Society's protocols. The following clinical stages were considered: single-system disease (A) divided into single-site (A1; n=4), multiple-site (A2; n=9), and multisystem disease (B) without organ dysfunction (B1; n=5) and with organ dysfunction (B2; n=14). Pretreatment concentrations of sIL-2r were markedly increased at diagnosis in LCH patients compared with controls [in pg/ml, median (range) 9200 (1124-40000) versus 610 (343-800)], P < 0.0001. Levels differed significantly between stages A [3250 (1124-11000)] and B [22750 (3400-40000)], P < 0.05, and between substages A2 and B2, P < 0.05. There was a significant correlation between clinical stages and sIL-2r serum levels, r=0.7996 (P < 0.0001). Patients with > or = 17500 pg/ml of sIL-2r had a 30-month survival of 0.417 (SEM: 0.142) compared with those with levels < 17500 pg/ml,...Continue Reading

References

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Citations

Nov 19, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Joan Manel Gasent BlesaCarlos Rodríguez-Galindo
Sep 3, 2004·Journal of Pediatric Hematology/oncology·Tadashi MatsubayashiRie Matsubayashi
Oct 6, 2012·Journal of Clinical and Experimental Hematopathology : JCEH·Mitsuhiro YuasaKeiya Ozawa
Jan 28, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Satoshi TsutsumiYukimasa Yasumoto
Mar 22, 2006·European Journal of Haematology·Marcus Stockschlaeder, Christoph Sucker
Aug 19, 2011·British Journal of Haematology·Thomas LehrnbecherMilen Minkov
Dec 7, 2006·International Review of Cytology·G I BechanR J Arceci
Sep 25, 2016·Pediatric Blood & Cancer·Jorge Braier
Feb 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ayalew TefferiAnimesh Pardanani
May 31, 2011·Clinical Pediatrics·Emily K Brumfield, Russell W Steele
Aug 30, 2017·Blood·Eugenio Antonio Carrera SilvaDiego Alfredo Rosso
Mar 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carl E AllenKenneth L McClain
Nov 1, 2007·Expert Review of Endocrinology & Metabolism·Polyzois MakrasGregory A Kaltsas
Nov 16, 2004·The British Journal of Dermatology·M-W LeeJ-K Koh
Jun 17, 2021·Journal of Pediatric Hematology/oncology·Xue TangZhi Wan

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