Prognostic value of soluble P-selectin levels in colorectal cancer

International Journal of Cancer. Journal International Du Cancer
Patrizia FerroniFiorella Guadagni

Abstract

Measurement of soluble (s) P-selectin levels has been proposed as a diagnostic tool for monitoring the clinical course of human neoplasms. Thus, our study was aimed at analyzing the role of sP-selectin in association with clinicopathological variables in 181 patients with primary (n =149) or metastatic (n = 32) colorectal cancer (CRC), 34 patients with benign diseases and 181 control subjects. The results obtained showed that sP-selectin levels were higher in patients with CRC compared either to patients with benign disease (p = 0.006) or controls (p = 0.003). No differences were observed between the latter and patients with benign diseases. Increased median sP-selectin levels were significantly associated with the presence of distant metastasis (68.2 ng/ml vs. 48.6 ng/ml, p = 0.002). Of interest, carcinoembryonic antigen (CEA) levels were independently associated to sP-selectin (regression coefficient = 0.28, p < 0.002). Cox's proportional hazards survival analysis of primary CRC patients demonstrated that beside the stage of disease sP-selectin levels had an independent prognostic role in predicting recurrent disease (HR = 2.22, p = 0.019) and mortality from CRC (HR = 3.44, p= 0.017). These results suggest that measurement of...Continue Reading

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Citations

Apr 22, 2014·Cancer Metastasis Reviews·M RoselliF Guadagni
Nov 17, 2009·Cancer Investigation·Nektaria MakriliaKostas Syrigos
Dec 7, 2013·Hämostaseologie·J RiedlC Ay
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Oct 25, 2013·Cancer Medicine·Niamh M CookeDermot Kenny
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Oct 25, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Aleksandra KornilukVioletta Dymicka-Piekarska
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