Prognostic Value of Soluble Programmed Cell Death Ligand-1 (sPD-L1) in Various Cancers: A Meta-analysis.

Targeted Oncology
Xiaoyang LiFei Yue

Abstract

The prognostic value of soluble programmed cell death ligand-1 (sPD-L1) in patients with cancer has been inconsistent across previous studies. This meta-analysis aimed to investigate the prognostic significance of sPD-L1 in human tumors. A comprehensive search of PubMed, Web of Science, Embase, and Cochrane databases from inception to January 6, 2020 was conducted. Studies of sPD-L1 measured by enzyme-linked immunosorbent assay (ELISA) that had available hazard ratios (HRs) for survival outcomes based on high or low sPD-L1 levels were included. The primary endpoint was long-term survival, namely, overall survival (OS), and the second endpoint was short-term survival, including progression-free survival (PFS), disease-free survival (DFS), recurrence-free survival (RFS), and cancer-specific survival (CSS). A total of 21 studies, with 2413 patients, were included in this meta-analysis. Elevated sPD-L1 was associated with worse OS [HR = 2.46, 95% confidence interval (CI) 1.74-3.49, P < 0.001]. Moreover, high sPD-L1 was predictive of worse PFS/DFS/RFS/CSS (HR = 2.22, 95% CI 1.47-3.35, P < 0.001). High sPD-L1 was consistently correlated with poor OS and PFS/DFS/RFS/CSS irrespective of study design, sample, and cut-off value of sPD-L1...Continue Reading

References

Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
May 27, 2008·Nature Reviews. Immunology·Weiping Zou, Lieping Chen
Jul 28, 2009·Journal of Clinical Epidemiology·David MoherUNKNOWN PRISMA Group
Mar 22, 2014·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Zhixue ZhengJiafu Ji
Aug 8, 2014·The Cancer Journal·Miguel F Sanmamed, Lieping Chen
Jun 27, 2015·PloS One·Pin WuJian Huang
Oct 30, 2016·The International Journal of Biological Markers·Jung-Soo PyoJung Yeon Kim
Jan 10, 2017·Journal of Thoracic Disease·Chad Tang, Joe Y Chang
Feb 19, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yusuke OkumaSadamu Homma
Feb 19, 2017·Cancer Immunology, Immunotherapy : CII·Arjun Vasant Balar, Jeffrey S Weber
Nov 15, 2017·Expert Review of Molecular Diagnostics·Lidia Maria Rebolho Batista ArantesAndré Lopes Carvalho
Jan 26, 2018·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hyun Ju KimJinsil Seong
Mar 22, 2018·Immunity·Chong SunTon N Schumacher
Jun 13, 2018·Esophagus : Official Journal of the Japan Esophageal Society·Yasunori AkutsuHisahiro Matsubara
Jun 19, 2018·Frontiers in Pharmacology·Yiting WangJie Xu
Sep 8, 2018·Journal of Cellular Physiology·Fatemeh K DermaniRezvan Najafi
Oct 1, 2018·Pharmacology & Therapeutics·Anastasia ConstantinidouDimitrios T Trafalis
Mar 16, 2019·The Journal of Experimental Medicine·Bo GongRyohei Katayama
Mar 22, 2019·JCI Insight·Mark YarchoanElizabeth M Jaffee
Jan 9, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S UgurelV Rebmann
Oct 1, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S VecchiarelliF Cappuzzo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.