Prognostic value of SUR in patients with trimodality treatment of locally advanced esophageal carcinoma

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Rebecca BütofMichael Baumann

Abstract

The prognosis of patients with esophageal carcinoma remains dismal despite ongoing efforts to improve treatment options. For locally advanced tumors, several randomized trials have shown the benefit of neoadjuvant chemoradiation followed by surgery compared to surgery alone. The aim of this exploratory study was to evaluate the prognostic value of different baseline positron emission tomography (PET) parameters and their potentially additional prognostic impact at the end of neoadjuvant radiochemotherapy. Furthermore, the standard uptake ratio (SUR) as a new parameter for quantification of tumor metabolism was compared to the conventional PET parameters metabolic active volume (MTV), total lesion glycolysis (TLG), and standardized uptake value (SUV) taking into account known basic parameters. Methods:18F-FDG-PET/CT was performed in 76 consecutive patients ((60±10) years, 71 males) with newly diagnosed esophageal cancer before and during the last week of neoadjuvant radiochemotherapy. MTV of the primary tumor was delineated with an adaptive threshold method. The blood SUV was determined by manually delineating the aorta in the low dose CT. SUR values were computed as scan time corrected ratio of tumor SUVmax and mean blood SUV. ...Continue Reading

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Citations

Mar 5, 2019·EJNMMI Research·Frank HofheinzJörg van den Hoff
Apr 6, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Frank HofheinzSebastian Zschaeck
Jan 24, 2020·BMC Medical Imaging·Styliani MantziariMarkus Schäfer
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