Prognostic value of surgical margins during endoscopic resection of paranasal sinus malignancy

International Forum of Allergy & Rhinology
Lakshman ManjunathPete S Batra

Abstract

Complete tumor resection with intraoperative frozen section control remains a central tenet of head and neck surgical oncology. The purpose of this study was to evaluate the significance of margins in predicting recurrence and disease status following endoscopic resection of sinonasal malignancy. This single-institution observational cohort study was performed on 68 patients over a 5-year period who underwent curative minimally invasive endoscopic resection (MIER) for sinonasal malignancies. The mean age was 58.8 years and 69.1% were male. The mean follow-up after definitive MIER was 15.9 months. A mean of 10.8 margins were taken per surgery (range, 2 to 27). False-negative frozen section analysis was 22.1% for the entire cohort, but slightly higher at 25.0% for T3 or T4 malignancies. At last follow-up, no evidence of disease (NED) status was noted in 60.0% of those with positive margins vs 83.0% in those with negative margins, respectively (p = 0.0795). Regional or distant recurrences were observed in 39.9% of patients with positive margins and 13.2% of those with negative margins, respectively (p = 0.0299). Disease-free survival (DFS) was 9.7 months for patients with positive margins, whereas it was 15.9 months for patients w...Continue Reading

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Citations

Feb 3, 2016·Head and Neck Pathology·Christopher R RoxburyGary L Gallia
Aug 23, 2019·International Forum of Allergy & Rhinology·Aria JafariAdam S DeConde
Aug 9, 2017·The Laryngoscope·Thérèse E M van DoeverenI Bing Tan
Aug 13, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S RacadotJ Thariat
Jul 27, 2021·Journal of Neurological Surgery. Part B, Skull Base·Tiffany N ChaoBert W O'Malley

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