Prognostic value of the heart rate profile during exercise in patients with atrial fibrillation

European Journal of Preventive Cardiology
Kazufumi AiharaTakeshi Yamashita

Abstract

Aims This study aimed to investigate the correlation of heart rate profile during exercise with exercise capacity and heart failure occurrence in patients with atrial fibrillation compared with patients with sinus rhythm. Methods We analyzed 2231 patients (atrial fibrillation: n = 321, sinus rhythm: n = 1910) who underwent a symptom-limited maximal cardiopulmonary exercise test at our institute. Their heart rate profile during exercise was assessed using peak heart rate and chronotropic response; (peak heart rate-resting heart rate)/(220-age-resting heart rate). The endpoint was the occurrence of heart failure events, defined as hospitalization for heart failure or heart failure-related death. Results There were significant positive correlations of peak heart rate and chronotropic response to peak oxygen consumption, both in atrial fibrillation and sinus rhythm. During a median follow-up period of 1262 (interquartile range 974-2921) days, 117 (5.2%) heart failure events were observed. Multivariate analyses showed that peak heart rate and chronotropic response were statistically significant predictors of heart failure events both in atrial fibrillation (peak heart rate: heart rate 0.975, p = 0.002, chronotropic response: heart r...Continue Reading

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Citations

Jan 9, 2019·European Journal of Preventive Cardiology·Yuko KatoTakeshi Yamashita
Mar 17, 2020·European Journal of Preventive Cardiology·Massimo F Piepoli

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