Prognostic value of the microRNA-214 in multiple human cancers: a meta-analysis of observational studies

Oncotarget
Yajing FengZhenxing Yang

Abstract

Previous studies showed that microRNA-214 (miR-214) may act as a prognostic biomarker of cancer. However, the available evidence is controversial. This study summarizes evidence and evaluates the prognostic role of miR-214 in various cancers. We carried out a systematic literature review and assessed the quality of included studies based on Oxford Centre for Evidence-based Medicine Criteria and Newcastle-Ottawa Scale (NOS). Pooled hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) for overall survival (OS) and disease free survival/progressive free survival/recurrence free survival (DFS/PFS/RFS) were calculated to measure the effective value of miR-214 expression on prognosis. Thirteen studies were included in pooled analysis. We found that miR-214 was significantly correlated with OS (HR=2.21, 95%CI: 1.33-3.68, P=0.00), no significant difference was found with DFS/PFS/RFS (HR=1.73, 95%CI: 0.78-3.83, P=0.18) in various carcinomas. In subgroup analysis, higher expression of miR-214 was significantly associated with poor OS in Asians (HR=2.27, 95%CI: 1.09-4.73, P=0.00) and Caucasians (HR=2.04, 95%CI: 1.47-3.30, P=0.00). On the contrary, high miR-214 expression significantly predicted favorable DFS/PFS/RFS (HR=0...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jul 12, 2002·Statistics in Medicine·Simon G Thompson, Julian P T Higgins
Jan 7, 2005·The FEBS Journal·Michel J Weber
Jul 29, 2008·The Journal of Surgical Research·Mary DillhoffMark Bloomston
Nov 26, 2008·Nucleic Acids Research·Youn-Bok LeeJames B Uney
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Jul 30, 2009·British Journal of Cancer·D W Mueller, A K Bosserhoff
Mar 30, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Shai RosenwaldRanit Aharonov
Nov 26, 2010·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Vladimir A Krutovskikh, Zdenko Herceg
Jun 22, 2011·RNA Biology·R Stephanie HuangM Eileen Dolan
Oct 17, 2012·Biochemical and Biophysical Research Communications·Xiaojun WangJiaji Jiang
Jan 23, 2013·Cellular Oncology (Dordrecht)·Rahul NagadiaChamindie Punyadeera
Feb 20, 2013·Annals of Internal Medicine·Jill A HaydenClaire Bombardier
Aug 22, 2013·Biochemical and Biophysical Research Communications·Jian WangWeidong Ma
Nov 26, 2013·Clinics in Laboratory Medicine·Seema SethiFazlul H Sarkar
Mar 13, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dong-Liang ChenRui-Hua Xu
May 3, 2014·Molecular Medicine Reports·Keqiang HanLiang Wang
Jun 7, 2014·Cancer Medicine·Sirjana ShresthaHsien-Da Huang
Jan 17, 2015·Future Oncology·Tanu SharmaChandi C Mandal
Feb 24, 2015·Hereditary Cancer in Clinical Practice·Dagnija KalnieteEdvīns Miklaševičs
May 23, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Qiaoyun ChenYangchen Liu
Jan 29, 2016·Journal of Cancer Science & Therapy·Shadan AliFazlul H Sarkar

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Citations

Jun 15, 2018·Oncotarget·Oriol BachsMaria Jesús Pujol
Mar 9, 2019·Current Drug Targets·Seyed Mostafa ParizadehAmir Avan

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Software Mentioned

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Meta - analysis of Observational Studies in Epidemiology group...

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