Prognostic value of the new IASLC/ATS/ERS classification of clinical stage IA lung adenocarcinoma

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Shuji MurakamiHaruhiko Nakayama

Abstract

We analyzed and validated the prognostic utility of the new International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) for clinical stage IA lung adenocarcinoma (ADC) classification of adenocarcinoma (ADC). We retrospectively reviewed 347 patients with clinical stage IA nonmucinous ADC, who had undergone complete resection. The histological subtype was classified according to the predominant subtype, as proposed by the new IASLC/ATS/ERS ADC classification. The histopathological subtypes, defined according to the new IASLC/ATS/ERS ADC classification, were ADC in situ (AIS) in 56 patients (16.1%), minimally invasive ADC (MIA) in 15 (4.3%), lepidic-predominant ADC in 109 (31.4%), papillary-predominant ADC in 70 (20.2%), acinar-predominant ADC in 61 (17.6%), solid-predominant ADC in 30 (8.6%), and micropapillary-predominant ADC in 6 (1.7%). The 5-year disease-free survival (DFS) rate was 100% for both AIS and MIA. All cases of recurrence involved invasive ADC. The 5-year DFS for lepidic-predominant ADC was 99.0%; acinar-predominant ADC, 82.4%; papillary-predominant ADC, 80.8%; solid-predominant ADC, 73.6%; and micropapillary-predominant ADC, 33.3%. The predomina...Continue Reading

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Citations

Jul 10, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jie DaiGening Jiang
Feb 12, 2019·Diagnostic Cytopathology·Ryota TanakaHaruhiko Kondo
Dec 3, 2016·European Respiratory Review : an Official Journal of the European Respiratory Society·Alain C Borczuk
Apr 2, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David Allan MooreJohn Le Quesne
May 8, 2018·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Meng LiDongmei Lin
Dec 15, 2020·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Fenghao SunQun Wang

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