PMID: 11337298May 19, 2001Paper

Prognostic value of three molecular forms of prostate-specific antigen ratios in patients with prostate adenocarcinoma

Urology
T OkegawaE Higashihara

Abstract

To investigate whether different molecular forms of prostate-specific antigen (PSA) ratios could provide prognostic information about the stage and grade of prostate cancer. Serum specimens were examined from 53 patients who underwent radical prostatectomy for clinically localized prostate cancer and from 94 patients diagnosed as having no evidence of malignancy (total PSA between 4.1 and 20.0 ng/mL). The free/total PSA (fPSA/tPSA) ratio and complexed/total PSA (cPSA/tPSA) ratio in 18 patients with biochemical recurrence were compared with those of patients either without recurrence or with no evidence of malignancy. The fPSA/tPSA and cPSA/tPSA ratios differed significantly (P <0.05) between patients with organ-confined and those with non-organ-confined disease, but the tPSA, cPSA, and fPSA levels did not (P >0.05). The median values of the fPSA/tPSA ratio in patients with recurrence (7.0%) were significantly lower than in the patients without recurrence (8.9%) or those without evidence of malignancy (15.2%) (P = 0.02 and P <0.01, respectively). The median values of the cPSA/tPSA ratio in patients with recurrence (97.4%) were significantly higher than in patients without recurrence (92.9%) or those without evidence of malignanc...Continue Reading

References

Jan 1, 1991·Acta Oncologica·M K Brawer
Mar 1, 1994·International Journal of Urology : Official Journal of the Japanese Urological Association·M YamamotoK Miyake
Feb 1, 1997·The Journal of Urology·C H BangmaF H Schröder
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·A Y LiuG van den Engh

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