Prognostic value of total number of lymph nodes retrieved differs between left-sided colon cancer and right-sided colon cancer in stage III patients with colon cancer

BMC Cancer
Lin YangLiangping Xia

Abstract

The consensus is that a minimum of 12 lymph nodes should be analyzed at colectomy for colon cancer. However, right colon cancer and left colon cancer have different characteristics, and this threshold value for total number of lymph nodes retrieved may not be universally applicable. The data of 63,243 patients with colon cancer treated between 2004 and 2012 were retrieved from the National Cancer Institute's Surveillance, Epidemiology, and End Results database. Multivariate Cox regression analysis was used to determine the predictive value of total number of lymph nodes for survival after adjusting for lymph nodes ratio. The predictive value in left-sided colon cancer and right-sided colon cancer was compared. The optimal total number of lymph nodes cutoff value for prediction of overall survival was identified using the online tool Cutoff Finder. Survival of patients with high total number of lymph nodes (≥12) and low total number of lymph nodes (< 12) was compared by Kaplan-Meier analysis. After stratifying by lymph nodes ratio status, total number of lymph nodes≥12 remained an independent predictor of survival in the whole cohort and in right-sided colon cancer, but not in left-sided colon cancer. The optimal cutoff value fo...Continue Reading

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Citations

Jun 26, 2020·Digestive Diseases and Sciences·Augusto LauroValeria Tonini
May 19, 2020·World Journal of Surgical Oncology·Yen-Jen ChenChen-Sung Lin
Oct 14, 2020·Journal of Gastrointestinal Cancer·Younis MohdVijaya Anand Arumugam
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May 14, 2021·BMC Public Health·Lucia MangonePaolo Giorgi Rossi
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Software Mentioned

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