Prognostic value of tumor growth factor levels during chemotherapy in patients with metastatic colorectal cancer.

Medical Oncology
M InancFerhan Elmalı

Abstract

Tumor growth and angiogenic factors are usually overexpressed in colorectal carcinomas. We aimed to assess the prognostic role of VEGF, bFGF, PDGF-AA, EGF, HGF, and E-selectin in patients with metastatic colorectal cancer treated with capecitabine and oxaliplatin (XELOX) chemotherapy protocol. Thirty-eight colorectal cancer patients who had evidence of distant metastasis were enrolled in the study. Angiogenic factors were measured before and after third cycle of chemotherapy. Patients were randomized into three groups, partial response (PR), stable disease (SD), and progressive disease (PD) groups, according to their clinical and radiologic evaluation after three cycles of XELOX chemotherapy. Eighteen patients (47.3 %) achieved partial response, 10 (26.3 %) stable disease, and 10 (26.3 %) progressive disease. VEGF (63.20 Pg/ml vs. 19,79 Pg/ml; p < 0.001), EGF (7.29 ± 3.08 Pg/ml vs. 4.79 ± 2.05 Pg/ml; p < 0.011), HGF (618.16 ± 340.39 Pg/ml vs. 452.02 ± 217.18 Pg/ml; p < 0.049), and PDGF-AA (691.68 ± 187.10 Pg/ml vs. 404.89 ± 168.47 Pg/ml; p < 0.001) were significantly decreased in PR group. PDGF-AA levels were also decreased in SD group (706.66 ± 206.66 Pg/ml vs. 389.79 ± 143.16 Pg/ml; p < 0,001). HGF levels were significantly i...Continue Reading

References

Aug 1, 1996·Biochemical Society Transactions·Z GalzieA R Kinsella
Apr 21, 1998·Surgery Today·T KitagawaK Iriyama
Feb 1, 2000·International Journal of Cancer. Journal International Du Cancer·L UhrbomB Westermark
Apr 26, 2000·Cancer Letters·T YoshikawaY Noguchi
Aug 17, 2000·Journal of the National Cancer Institute·G J ByrneN J Bundred
Feb 22, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R T PoonJ Wong
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·Y Yarden, M X Sliwkowski
Nov 27, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D AlexiouC Tsigris
Jun 7, 2003·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Reinhard KoppAndreas Pfeiffer
Oct 8, 2003·Diseases of the Colon and Rectum·Reinhard KoppAndreas Pfeiffer
Nov 25, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tobias NübelGerhard Fritz
Feb 19, 2004·Acta Oncologica·Kim WertherUNKNOWN Danish RANX05 Colorectal Cancer Study Group
May 3, 2005·Cytokine & Growth Factor Reviews·Marco PrestaMarco Rusnati
Dec 16, 2005·Nature·Napoleone Ferrara, Robert S Kerbel
Feb 3, 2006·International Journal of Cancer. Journal International Du Cancer·Kunio Matsumoto, Toshikazu Nakamura
Sep 22, 2006·International Journal of Cancer. Journal International Du Cancer·Yasuhiko KitadaiIsaiah J Fidler
Apr 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce J GiantonioUNKNOWN Eastern Cooperative Oncology Group Study E3200
May 2, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric Van CutsemRafael G Amado
May 15, 2008·Annals of Surgical Oncology·Yoshito NakamuraMasaki Mori
Jun 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fiona GintyMichael C Montalto
Oct 24, 2008·The New England Journal of Medicine·Christos S KarapetisJohn R Zalcberg
Dec 31, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carsten BokemeyerPiotr Koralewski
Feb 21, 2009·International Journal of Cancer. Journal International Du Cancer·Dong Soon ChoiHee-Sug Ryu
Feb 24, 2009·Current Opinion in Cell Biology·Marja LohelaKari Alitalo
Apr 3, 2009·The New England Journal of Medicine·Eric Van CutsemPhilippe Rougier
Dec 17, 2009·British Journal of Cancer·N MurukeshG C Jayson
Jun 26, 2010·Japanese Journal of Clinical Oncology·Harunobu SatoKoutarou Maeda

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Citations

Oct 23, 2018·Cancer Biology & Therapy·Elisabetta CavalcantiMaria Lucia Caruso
Feb 18, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Mevlude InancOktay Bozkurt
Apr 4, 2021·Cancers·Cristina Galindo-PumariñoCristina Peña
Oct 22, 2021·Molecular and Clinical Oncology·Maha-Hamadien AbdullaOmar Abdullah Al-Obeed

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