Prognostic value of tumor infiltrating lymphocyte subsets in breast cancer depends on hormone receptor status

Breast Cancer Research and Treatment
Yul Ri ChungSo Yeon Park

Abstract

Interaction between immune-regulatory proteins and tumor infiltrating lymphocytes (TILs) is complex, and their associations may have significant clinical implications. This study was designed to evaluate the relationships between immunomodulatory proteins and TIL subsets and their impact on prognosis in breast cancer. 377 invasive breast cancer cases were selected, and immunohistochemistry was performed for HLA-A, HLA-ABC, and indoleamine 2,3-dioxygenase (IDO); CD4+, CD8+, and FOXP3+ T cells were counted in intratumoral and stromal areas for both absolute numbers as well as their ratios. While HLA-ABC and HLA-A expressions showed a positive correlation with CD8+ and FOXP3+ TIL infiltration, IDO expression showed a negative correlation with FOXP3+/CD4+ and FOXP3+/CD8+ T cell ratios. Expressions of HLA-ABC, HLA-A, and IDO shared an association with negative estrogen receptor status. Infiltration of CD4+, CD8+, and FOXP3+ TILs was significantly higher in tumors with high histologic grade, negative hormone receptor status, HER2 amplification, high Ki-67 index, and p53 overexpression. In survival analyses, increased CD4+ TIL infiltration was associated with better prognosis of the patients while other TIL subset infiltration and exp...Continue Reading

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Nov 15, 2018·Journal of Pathology and Translational Medicine·Hong Sik ParkHyun Joo Choi
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Related Concepts

Mammary Neoplasms, Human
HLA Antigens
Immunocytochemistry
Neoplasm Metastasis
TNM Staging System
Viral Markers
Cox Proportional Hazards Models
Lymphocyte Subset
Lymphocytes, Tumor-Infiltrating
Cell Microarray Analysis

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