Prognostic value of tumour deposit and perineural invasion status in colorectal cancer patients: a SEER-based population study

Histopathology
Erin MayoLanjing Zhang

Abstract

The definition of tumour deposit (TD) in colorectal cancer (CRC) was changed recently in the American Joint Commission on Cancer (AJCC) Staging Manual, 7th edition. We aimed to examine the prognostic values of the newly defined TD and perineural invasion (PNI) in this population study. We identified the incidental CRC cases with known TD or PNI status in the Surveillance, Epidemiology, and End Results (SEER) programme diagnosed in 2010 and 2011. Kaplan-Meier survival analysis and multivariable Cox proportional hazards models were used to estimate overall survivals (OS) and cancer-specific survival (CSS). We found that 6.71% (2774 of 41 323) of the CRC cases were positive for TD and 9.61% (3970 of 41 215) positive for PNI. In multivariable models, TD- and PNI-positive statuses correlated independently with worse 3-year OS [hazard ratio (HR): 1.68, 95% confidence interval (CI): 1.58-1.80 and HR: 1.24, 95%: CI: 1.16-1.32, respectively] and 3-year CSS (HR: 1.79, 95% CI: 1.65-1.94 and HR: 1.28, 95% CI: 1.18-1.38, respectively, P < 0.001 for all). Other independent prognostic factors included age, T category, N category, tumour location and tumour grade, but not gender. TD and PNI correlated with worse OS in all N categories (P < 0.0...Continue Reading

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Citations

Jul 25, 2017·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Ko-Chao LeeChien-Chang Lu
Jun 13, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M BouquotM Svrcek
Jun 16, 2019·International Journal of Colorectal Disease·Feng Shen, Xia Hong
Aug 24, 2019·European Journal of Gastroenterology & Hepatology·Wanbin HeZiqiang Wang
May 13, 2020·Cancer Causes & Control : CCC·Meifang ZhangLanjing Zhang
Mar 23, 2017·Frontiers in Medicine·Jesús M CortésJosé I López
Apr 8, 2020·Gastroenterology Research and Practice·Kuo ZhengWei Zhang
Jun 10, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Qingqing Liu, Alexandros D Polydorides
Dec 11, 2020·Gastroenterology Research and Practice·Yuqiang LiHong Zhu
Feb 13, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Fei DengLanjing Zhang
Oct 17, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Hillary L SimonDeborah S Keller
May 28, 2021·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Yan-Song YangYue-Tao Wang

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