Prognostic value of tumour regression grading and depth of neoplastic infiltration within the perirectal fat after combined neoadjuvant chemo-radiotherapy and surgery for rectal cancer

Journal of Clinical Pathology
E BenzoniC Avellini

Abstract

To evaluate histological variables correlated with pathological response to chemo-radiotherapy protocols for rectal cancer and with local recurrence and survival. From 1994 to 2003, 58 patients with rectal cancer were enrolled in a non-randomised study based on standardised treatment with radiotherapy, 5-fluorouracil, and surgical resection, followed by histological examination, including tumour regression grading and depth of neoplastic infiltration within the perirectal fat. All patients were followed up. Mean (SD) length of follow up was 55.3 (28.1) months, range 5 to 108. No case was found with no regression (grade 0). Tumour regression was defined as grade 1 in 24.5% of cases, grade 2 in 58.5%, grade 3 in 7.5%, and grade 4 (complete regression) in 9.5%. Neoplastic infiltration of >4 mm within the perirectal fat was found in 25.6% of cases in grade 1, 55.8% in grade, 2.7% in grade 3, and 11.6% in grade 4. In 80% cases of pT4 depth of neoplastic infiltration within the perirectal fat was >4 mm (100% were pN+), and the same spread was also found in 53.4% of pT2 and 86.2% of pT3. Pathological response was associated with regression grade (p = 0.006) and depth of neoplastic infiltration within the perirectal fat (p = 0.04). Tum...Continue Reading

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Citations

Jun 25, 2008·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J LindebjergA Jakobsen
Jul 22, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·V S RamaniH Wong
May 19, 2011·Annals of Surgical Oncology·Oliver C ShihabGina Brown
Apr 26, 2011·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·B FarnaultM Resbeut
Nov 26, 2010·International Journal of Radiation Oncology, Biology, Physics·Laurence Moureau-ZabottoNaji Salem

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