PMID: 8583593Mar 1, 1996Paper

Prognostic value of urokinase plasminogen activator and plasminogen activator inhibitor-1 in renal cell cancer

The Journal of Urology
R HofmannF Grothe

Abstract

Urokinase type plasminogen activator and its inhibitor plasminogen activator inhibitor are associated with invasion and formation of metastases in tumors. In a prospective study urokinase and plasminogen activator inhibitor-1 content in renal cell cancer and benign renal tissue was correlated with the traditional factors of TNM staging and grading as well as ploidy and actual clinical outcome of the patients. A total of 152 patients, who underwent transperitoneal tumor nephrectomy for renal cell cancer, was followed for a mean of 23.9 months. Urokinase and plasminogen activator inhibitor-1 from the tumor tissue and corresponding benign renal tissue were quantified from detergent extracted tissue samples (1% triton-X = 100 in TBS) and measured with an enzyme-linked immunosorbent assay. Urokinase content correlated with the development of distant metastases (log rank 4.32, p = 0.037). Cutoff value was 0.84 ng/mg. A group of 11 patients were considered to be at high risk for metastases (9 events) based on urokinase greater than 0.84 ng/mg., while 94 patients were considered to be at low risk (5 events) with urokinase less than 0.84 ng/mg. Plasminogen activator inhibitor-1 significantly correlated with the prevalence of distant met...Continue Reading

Citations

Mar 1, 1997·Electrophoresis·C SartoP Mocarelli
Jun 8, 2006·Journal of the National Cancer Institute·Jaime R MerchanVikas P Sukhatme
Feb 20, 2014·Medicinal Research Reviews·Ahmed H MekkawyDavid L Morris
Oct 23, 2010·Expert Review of Molecular Diagnostics·Karin MengeleManfred Schmitt
Nov 18, 2010·Expert Review of Molecular Diagnostics·Manfred SchmittNadia Harbeck

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