Prognostic value of various subtypes of extracellular DNA in ovarian cancer patients

Journal of Ovarian Research
Katarina KalavskaMichal Mego

Abstract

Patients with ovarian cancer represent a heterogeneous population with a variable prognosis and response to chemotherapy. Plasma DNA has been shown to have a prognostic value in different types of cancer including ovarian carcinoma. Whether total circulating DNA, which can be assessed much easier without knowing the tumor-specific mutations, has similar informative value is currently unknown. The aim of this study was to evaluate the prognostic value of extracellular DNA in advanced ovarian cancer. This prospective study included 67 patients (pts) with ovarian cancer treated with 1st line paclitaxel and carboplatin (25 pts) and paclitaxel, carboplatin and bevacizumab (42 pts). Thirty-five patients had optimal surgical debulking before chemotherapy. Extracellular DNA was quantified using real time PCR before administration of chemotherapy (67 pts) and after 6 cycles of chemotherapy (44 pts). Total extracellular DNA (ecDNA), as well as extracellular DNA of nuclear (nDNA) and mitochondrial origin (mtDNA) significantly (p < 0.05) decreased after 6 cycles of chemotherapy (by 54%, 63% and 52%, respectively. Patients with stage I disease had significantly lower mtDNA compared to patients with stage II-IV (8604 vs. 16, 984 ge/mL, p = 0...Continue Reading

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Citations

Feb 15, 2019·Cell Structure and Function·Shan SuJu Chen
Apr 28, 2021·Cancer Cell International·Yihao WangJianfeng Shen
May 1, 2021·Carcinogenesis·Pallavi Shukla, Keshav K Singh
Nov 25, 2021·Technology in Cancer Research & Treatment·Yuanyuan Lu, Li Li

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Methods Mentioned

BETA
imaging techniques
biopsy
surgical resection
blood draw
Assay
PCR

Software Mentioned

NCSS

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