Prognostic value of vascular endothelial growth factor and hypoxia-inducible factor 1α in canine malignant mammary tumors

Oncology Reports
Marina Gobbe MoschettaDebora Aparecida Pires De Campos Zuccari

Abstract

Mammary tumors are the most common type of tumor in dogs, with approximately half of these tumors being malignant. Hypoxia, characterized by oxygen levels below normal, is a known adverse factor to cancer treatment. The hypoxia-inducible factor 1α (HIF-1α) is a central regulator of the pathophysiological response of mammalian cells to low oxygen levels. HIF-1α activates the transcription of vascular endothelial growth factor (VEGF), which in turn promotes angiogenesis through its ability to stimulate the growth, migration and invasion of endothelial cells to form new blood vessels, contributing to tumor progression. In this study, we evaluated the serum concentration and gene expression of VEGF and HIF-1α linking them with clinicopathological parameters and survival of dogs with mammary tumors in order to infer the possible prognostic value of these factors. We collected blood and tumor fragments of 24 female dogs with malignant mammary tumors (study group) and 26 non-affected female dogs (control group) to verify the gene expression of VEGF and HIF-1α by quantitative real-time PCR (qPCR) and the serum levels by ELISA (enzyme-linked immunosorbent). The results showed high serum levels of VEGF in the study group and its correlat...Continue Reading

References

Mar 21, 2002·Nature Reviews. Cancer·Adrian L Harris
Apr 3, 2002·Trends in Molecular Medicine·Gregg L Semenza
Mar 9, 2004·Journal of Comparative Pathology·B RestucciS Papparella
Feb 7, 2007·The Journal of Veterinary Medical Science·Yuka KatoShigeo Tanaka
Sep 7, 2007·Breast Cancer Research and Treatment·Yutaka YamamotoHirotaka Iwase
May 8, 2008·Veterinary Research Communications·C W QiuG Z Deng
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Nov 8, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Manuela Milani, Adrian L Harris
Nov 11, 2008·The Breast : Official Journal of the European Society of Mastology·Derya DuranyildizVildan Yasasever
Jun 6, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Laura SpencerAshley Dennison
Jan 29, 2010·Breast Cancer Research and Treatment·Emad A RakhaIan O Ellis
Feb 19, 2010·The Cancer Journal·Sally Greenberg, Hope S Rugo
Jun 23, 2010·Clinical Medicine Insights. Oncology·Pankaj TanejaKazushi Inoue
Jun 24, 2010·Molecular Cancer·Rodrigue RomonXuefen Le Bourhis
Jun 24, 2010·Journal of Comparative Pathology·A A F SantosA J F Matos
Jul 1, 2010·Diagnostic Pathology·Fábio He AndradeNoeme S Rocha
Dec 15, 2010·Veterinary Pathology·R KlopfleischA D Gruber
Oct 22, 2011·BMC Veterinary Research·Pei-Yi ChuChen-Hsuan Liu
Mar 13, 2012·Veterinary Immunology and Immunopathology·Gabriela Bottaro GelaletiDebora Ap Pires de Campos Zuccari
Apr 5, 2012·BMC Research Notes·Yasunaga YoshikawaKiyotaka Watanabe
Oct 19, 2012·International Journal of Oncology·Luis G Perez-RivasEmilio Alba
Jan 11, 2013·Journal of Cellular and Molecular Medicine·Murielle Mimeault, Surinder K Batra
Jan 30, 2013·Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists·Diana Hodorowicz-ZaniewskaKrystyna Sztefko
Aug 1, 2013·Acta histochemica·Larissa Bazela MaschioDebora Aparecida Pires de Campos Zuccari
Aug 2, 2013·International Journal of Molecular Sciences·Nikos G GavalasAristotle Bamias
Aug 21, 2013·Breast Cancer Research : BCR·Ernestina Marianna De FrancescoMarcello Maggiolini

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Citations

Dec 21, 2018·Anti-cancer Agents in Medicinal Chemistry·Marina G MoschettaDebora A P de Campos Zuccari
Oct 30, 2016·Microscopy Research and Technique·Talita M M Raposo-FerreiraRenée Laufer-Amorim
Oct 31, 2018·Acta Veterinaria Scandinavica·Ilona KaszakPiotr Jurka
Jan 11, 2020·Frontiers in Cell and Developmental Biology·Enni Markkanen

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