Prognostic value of vascular invasion in well-differentiated papillary thyroid carcinoma

Thyroid : Official Journal of the American Thyroid Association
Volkert B WreesmannRonald Ghossein

Abstract

Vascular invasion (VI) is an important predictor of distant metastasis and possible radioactive iodine (RAI) benefit in follicular, Hürthle cell, and poorly differentiated thyroid carcinomas, but its role in well-differentiated papillary thyroid cancer (WDTC) remains unclear. Archived pathological material of all differentiated thyroid carcinoma patients undergoing primary surgical treatment at Memorial Sloan-Kettering Cancer Center between 1986 and 2003 was reviewed by two dedicated thyroid pathologists. Only WDTCs were included in the present study. Standard statistical methods were used to assess the relationship between VI and outcomes of interest, including 10-year disease-specific survival (DSS), regional recurrence-free survival (RRFS), and distant recurrence-free survival (DRFS). VI was present in 47 of 698 WDTC (6.7%). VI was significantly associated with tumor size >4.0 cm, extrathyroidal extension, distant metastasis, and RAI treatment. On univariate analysis, VI was predictive of decreased 10-year DRFS, but not DSS or RRFS. On multivariate analysis, VI was not an independent predictor of DRFS. Univariate survival analysis of 422 RAI-naïve WDTC showed that both size >4 cm and VI were predictors of outcome, but only s...Continue Reading

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Citations

Apr 12, 2018·Archives of Endocrinology and Metabolism·Fabián PitoiaAndrea Páes de Lima
May 18, 2018·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·I J NixonD Kim
Jul 25, 2018·Thyroid : Official Journal of the American Thyroid Association·Gilbert H Daniels
Apr 25, 2019·Endocrine-related Cancer·Jae Hyun Park, Jong Ho Yoon
May 31, 2017·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B Xu, R Ghossein

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Methods Mentioned

BETA
dissection
biopsy

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