Prognostic values of abdominal body compositions on survival in advanced pancreatic cancer

Medicine
Xiaojie BianWei Li

Abstract

To investigate the clinical impact of body composition on outcomes in advanced pancreatic cancer (APC), we performed a retrospective analysis of patients diagnosed with APC between 2010 and 2016. The extent of visceral fat, subcutaneous fat, and skeletal muscle was measured using computed tomography (CT) images, together with visceral to subcutaneous adipose tissue area ratio (VSR) and skeletal muscle index (SMI). The effects of these body composition parameters on survival in APC were explored. In total 203 APC patients were enrolled in this study, with a median age of 65 years (range: 31-80 years). The median overall survival (OS) was 9.5 months (95% confidence interval, 7.6-12.4 months). The survival analysis showed that OS in patients with high SMI was significantly longer than those in patients with low SMI (11.1 vs 8.0 months, P < .001). However, when analyzed with VSR, the OS in patients with high VSR was significantly shorter than those in patients with low VSR (8.3 vs 9.4 months, P < .001). Multivariate analyses revealed that ECOG performance status (hazard ratio [HR]: 1.56; P < .001), stage III (HR: 0.63; P = .039), SMI (HR: 0.92; P = .019), VSR (HR: 1.38; P = .005), and skeletal muscle area (HR: 0.95; P = .049) were ...Continue Reading

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Citations

Jan 24, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mayra Cruz-FernándezIrene Cantarero-Villanueva
Jul 20, 2019·Journal of Clinical Medicine·Julie MareschalLaurence Genton
Dec 24, 2021·Journal of Cachexia, Sarcopenia and Muscle·Akihiko TakagiNoriyuki Oba
Jan 15, 2022·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Maria Lopez-GarzonIrene Cantarero-Villanueva

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Software Mentioned

ImageJ
SPSS

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