Prognostic values of C-reactive protein levels on clinical outcome after endovascular therapy in hemodialysis patients with peripheral artery disease

Journal of Vascular Surgery
Hideki IshiiToyoaki Murohara

Abstract

Endovascular therapy (EVT) has been widely performed for peripheral artery disease. However, the high restenosis rate after EVT remains a major problem in patients on hemodialysis. Recent studies suggest that C-reactive protein (CRP) reflects vascular wall inflammation and can predict adverse events. We evaluated the possible prognostic values of CRP on outcomes in hemodialysis patients undergoing EVT. A total of 234 hemodialysis patients undergoing EVT for peripheral artery disease were enrolled and followed-up for up to 5 years. They were divided into tertiles according to serum CRP levels (lowest tertile, < 1.4 mg/L; middle tertile, 1.4-6.0 mg/L; highest tertile, ≥ 6.0 mg/L). We analyzed the incidence of any reintervention or above-ankle amputation of the limb index (RAO) and any-cause death. Kaplan-Meier analysis showed that the event-free rate from the composite end point of RAO and any-cause death for 5 years was 60.2% in the lowest tertile, 50.0% in the middle tertile, and 25.1% in the highest tertile (P < .0001). The survival rate from any-cause death for 5 years was 81.5% in the lowest tertile, 65.2% in the middle tertile, and 59.3% in the highest tertile (P = .0078). Even after adjusting for other risk factors at base...Continue Reading

References

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Dec 17, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hideki IshiiToyoaki Murohara

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Citations

May 21, 2015·International Journal of Molecular Sciences·Smriti Murali KrishnaJonathan Golledge
Feb 14, 2013·Annals of Vascular Surgery·Silvia BledaIgnacio López de Maturana
Nov 6, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hiroshi TakahashiYukio Yuzawa
Dec 25, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Junya MatsumiShigeru Saito
Mar 20, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Seiji HokimotoUNKNOWN Multi-center Study of Hemodialysis Patients Undergoing Invasive Cardiovascular Procedures Study Investigators
Oct 16, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jun ShiotaHitoshi Tagawa

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