Prognostic values of Notch receptors in breast cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Junming XuJun Liu

Abstract

Notch receptors are frequently deregulated in several human malignancies including human breast cancer. Activation of Notch has been reported to cause mammary carcinomas in mice. However, the prognostic value of individual Notch receptors in breast cancer (BC) patients remains elusive. In the current study, we investigated the prognostic value of Notch receptors in human BC patients. More specifically, we investigated the prognostic value of four Notch receptors in breast cancer patients through "the Kaplan-Meier plotter" (KM plotter) database, in which updated gene expression data and survival information are from a total of 3554 breast cancer patients. Our results showed that Notch1 messenger RNA (mRNA) high expression was correlated to worsen overall survival (OS) in PgR-negative BC patients. Notch2, Notch3, and Notch4 mRNA high expressions were found to be correlated to better OS for all breast cancer patients. Notch2 was also found to be correlated to better OS in lymph node-negative breast cancer patients and HER2-positive breast cancer patients. These results will be useful for better understanding of the heterogeneity and complexity in the molecular biology of breast cancer and for developing tools to more accurately pr...Continue Reading

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Citations

Mar 13, 2016·Breast Cancer Research and Treatment·Maria Cristina RangelDavid S Salomon
Jan 5, 2017·Scientific Reports·Shizhen ZhangXiaochen Wang
May 10, 2016·Scientific Reports·Cong WangYufeng Cheng
May 4, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·María-Luisa NuedaJorge Laborda
Apr 20, 2021·Genes & Development·Ajeya Nandi, Rumela Chakrabarti

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