Prognostic values of soluble CD30 and CD30 gene polymorphisms in heart transplantation

Transplantation
Elisa FrisaldiAntonio Amoroso

Abstract

Pretransplant soluble CD30 (sCD30) is a predictor of kidney graft outcome. Its status as a predictor of heart transplant (HT) outcome has not been established. We have studied this question by assessing sCD30 levels and the number of (CCAT)n repeats of the microsatellite in the CD30 promoter region, which is able alone to repress gene transcription, in the sera of 83 HT patients and 77 of their donors. sCD30 was non-significantly increased in the patients, whereas there were no differences in the CD30 microsatellite allele frequencies. A negative correlation between the number of (CCAT)n and sCD30 levels was evident in the donors. Patients with pretransplant sCD30<or=30 U/ml displayed a significantly better survival. In conclusion, sCD30 levels are predictive of HT outcome.

References

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Citations

Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Efthymios YpsilantisCraig J Taylor
Oct 18, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Johanna M Kwakkel-van ErpEd A van de Graaf
Sep 25, 2007·Transplantation Proceedings·E FábregaF P Romero
Dec 19, 2006·Transplantation Proceedings·I MatinlauriH Isoniemi
Dec 19, 2006·Transplantation Proceedings·C SpiridonA Nikaein
Dec 2, 2008·Clinical Transplantation·Camelia SpiridonMichael Mack
Sep 13, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D SainiT Mohanakumar
Nov 9, 2007·Clinical Transplantation·Afzal NikaeinMichael Mack

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