Prognostic values of the clinicopathological characteristics and survival outcomes in micropapillary urothelial carcinoma of the bladder: A SEER database analysis.

Cancer Medicine
Di JinQiang Wei

Abstract

To study prognostic values of the clinicopathological characteristics and survival outcomes in micropapillary urothelial carcinoma (MPUC) of the urinary bladder. We used the national Surveillance, Epidemiology, and End Results database (2004-2016) to compare MPUC with transitional cell carcinoma (TCC) and to investigate prognostic values of clinicopathological characteristics, as well as survival outcomes, in MPUC of the urinary bladder. A multivariable Cox proportional hazard model, subgroup analyses, and propensity score matching were used. In all, 519 patients with MPUC and 154 453 patients with TCC were enrolled. Compared with TCC, patients with MPUC had a higher rate of muscle invasive disease (P < .001), lymph node metastasis (P < .001), and distal metastasis (P < .001), as well as higher tumor grade (P < .001). According to the survival analyses, the MPUC group also had lower survival probability in both cancer-specific mortality (CSM) (P < .0001) and overall mortality (OM) analyses (P < .0001). Cox proportional hazard regression showed that the MPUC group had a higher risk of OM (hazard ratios [HR] = 1.39, 95% confidence intervals [CI] = 1.22-1.57, P < .0001), although the CSM (HR = 1.18, 95% CI = 1.00-1.40, P = .0505) ...Continue Reading

References

Sep 26, 2014·The Journal of Urology·Daniel L WillisAshish M Kamat
Mar 19, 2016·European Urology·Charles Chuanhai GuoBogdan Czerniak
Jul 3, 2016·European Urology·Sebastien AntoniFreddie Bray
Dec 31, 2016·Bladder Cancer·Wilson SuiSven Wenske
Nov 19, 2018·Surgical Pathology Clinics·Hikmat Al-Ahmadie, Gopa Iyer

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Citations

Dec 17, 2020·Cancers·Claudia Manini, José I López

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