Prognostic variables for the clinical success of flexible endoscopic septotomy of Zenker's diverticulum

Gastrointestinal Endoscopy
G CostamagnaA Bella

Abstract

Flexible endoscopy septotomy for Zenker's diverticulum (ZD) is an alternative to endostapling; however, long-term data are sparse and studies are heterogeneous. The aim of this study was to assess the clinical success of flexible endoscopy diverticuloscope-assisted septotomy according to all ZD-related symptoms and to identify potential prognostic variables. A prospective database of all patients with ZD undergoing septotomy and followed up for 24 months or longer was analyzed. Septotomy was conducted by using a diverticuloscope-assisted technique. Dysphagia, regurgitation, and respiratory symptoms (during the day and at night) were scored by their weekly frequency from 0 to 3 when on a solid food diet. Clinical success (asymptomatic state) was defined as a maximum of 2 symptoms with a score of 1 (once per week). Prognostic variables of clinical success included age, sex, pretreatment total symptom score, pre- and posttreatment ZD size, and septotomy length. The Kaplan-Meier method and Cox proportional hazards model were used to calculate the crude and adjusted hazard ratio (HR). Septotomy was attempted and achieved in a single session in 89 patients. Clinical success at the intention-to-treat analysis was 69%, 64%, and 46% at ...Continue Reading

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Citations

Jan 24, 2016·Gastrointestinal Endoscopy·Sauid IshaqAlessandro Repici
Dec 29, 2017·Journal of Clinical Gastroenterology·Deepanshu JainShashideep Singhal
Feb 10, 2018·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Sauid IshaqHelmut Neumann
Feb 23, 2019·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Toshio Kuwai, Sauid Ishaq
Apr 24, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Brianna CrawleyPhilip Weissbrod
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