PMID: 9542743May 30, 1998Paper

Prognosticating tools in primary neuroendocrine (Merkel-cell) carcinomas of the skin: histopathological subdivision, DNA cytometry, cell proliferation analyses (Ki-67-immunoreactivity) and NCAM immunohistochemistry. A clinicopathological study in 25 patients

Pathology, Research and Practice
C ParradoS Falkmer

Abstract

Histopathologically, 18 of our patients had classical Merkel-cell carcinomas (MCC); seven had neuroendocrine (NE) carcinomas with features different from MCC, here called "aberrant MCC". These patients showed a progressive neoplastic disease with a fatal outcome in four of them. The cytometric DNA distribution pattern of the tumor cell nuclei of all the aberrant MCCs was found to be of the aneuploid type. By contrast, the neoplastic disease of the majority of patients with classical MCC ran a milder course; a fatal outcome occurred in only one of them. Here, the DNA ploidy pattern was of the euploid (diploid or tetraploid) type in eight cases and of the aneuploid type in another eight. Our recently described "proliferation cell index" (PCI), based on nuclear immunoreactivity (IR) with the proliferation "marker" antigen Ki-67, was significantly lower in those five MCCs of the classical "DNA-diploid" type than in the seven "DNA-aneuploid" ones. These five patients presented a mild neoplastic disease; only one had a local recurrence and none had metastases. Otherwise, neither the PCI values nor the NCAM IR of the MCC cells were found to be of any prognostic significance.

References

May 1, 1995·Pathology, Research and Practice·U G Falkmer, S Falkmer
Feb 1, 1994·Journal of Cutaneous Pathology·N S Penneys, S Shapiro
Jun 1, 1995·American Journal of Clinical Oncology·D E SmithA V Peddada
Jun 1, 1995·Urology·S TomicG Wilding
Jan 1, 1995·Virchows Archiv : an International Journal of Pathology·R GallegoJ Forteza
Jan 15, 1995·International Journal of Radiation Oncology, Biology, Physics·F BoyleD Bell
Jan 15, 1995·International Journal of Radiation Oncology, Biology, Physics·J A MeeuwissenJ H Kearsley
Jan 1, 1994·European Journal of Nuclear Medicine·F De Geeter, E Saelens
Aug 1, 1993·Journal of the American Academy of Dermatology·D RatnerT M Johnson
Oct 1, 1993·Journal of the American Academy of Dermatology·W C Duncan, J A Tschen
Mar 1, 1996·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·W J O'Connor, D G Brodland
Jul 1, 1996·Virchows Archiv : an International Journal of Pathology·D Larsimont, A Verhest

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Citations

May 3, 2003·Journal of Dermatological Science·Motoki KurokawaMitsuru Setoyama
Jan 24, 2008·The American Journal of Dermatopathology·Trevor W BeerKevin Murray
Jun 30, 2007·Cancer·Sofia AsioliGianni Bussolati
Sep 27, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·L PozoS J Diaz-Cano
Nov 26, 2003·Histopathology·T García-CaballeroA Beiras

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