Program of cell survival underlying human and experimental hibernating myocardium

Circulation Research
Christophe DepreStephen F Vatner

Abstract

Hibernating myocardium refers to chronically dysfunctional myocardium in patients with coronary artery disease in which cardiac viability is maintained and whose function improves after coronary revascularization. It is our hypothesis that long-term adaptive genomic mechanisms subtend the survival capacity of this ischemic myocardium. Therefore, the goal of this study was to determine whether chronic repetitive ischemia elicits a gene program of survival protecting hibernating myocardium against cell death. Accordingly, we measured the expression of survival genes in hibernating myocardium, both in patients surgically treated for hibernation and in a chronic swine model of repetitive ischemia reproducing the features of hibernation. Human hibernating myocardium was characterized by an upregulation of genes and corresponding proteins involved in anti-apoptosis (IAP), growth (VEGF, H11 kinase), and cytoprotection (HSP70, HIF-1alpha, GLUT1). In the swine model, the same genes and proteins were upregulated after repetitive ischemia, which was accompanied by a concomitant decrease in myocyte apoptosis. These changes characterize viable tissue, because they were not found in irreversibly injured myocardium. Our report demonstrates a ...Continue Reading

References

Dec 1, 1986·Journal of the American College of Cardiology·E Braunwald, J D Rutherford
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·N B RadfordR S Williams
Oct 17, 1996·The New England Journal of Medicine·J NarulaB A Khaw
Apr 17, 1997·The New England Journal of Medicine·G OlivettiP Anversa
Jul 17, 1998·The New England Journal of Medicine·W WijnsP G Camici
Oct 28, 1998·Physiological Reviews·G Heusch
Sep 2, 1999·Journal of Molecular and Cellular Cardiology·T A HollyV L Cryns
Oct 12, 1999·The American Journal of Physiology·J A FallavollitaJ M Canty
Mar 23, 2000·Cardiovascular Research·C Depre, H Taegtmeyer
Oct 6, 2000·The Journal of Clinical Investigation·R S Williams, I J Benjamin
Nov 18, 2000·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·J M Canty, J A Fallavollita
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·E PalojokiI Tikkanen
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·C DepreS F Vatner
Feb 2, 2002·Current Atherosclerosis Reports·Dinesh K Kalra, William A Zoghbi
Nov 26, 2002·Cardiovascular Research·Hartmut LüssThomas Wichter
Nov 29, 2002·Circulation Research·Christophe DepreStephen F Vatner
Feb 5, 2003·Cardiovascular Research·Paolo G Camici, Ornella E Rimoldi

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Citations

Jun 20, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Gerald W Dorn, Abhinav Diwan
Jan 5, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Xiaoli ZhangHeinrich R Schelbert
Jun 2, 2007·Heart Failure Reviews·Christophe Depre, Stephen F Vatner
Jan 4, 2008·Heart Failure Reviews·Eloisa ArbustiniJagat Narula
Dec 1, 2008·Journal of Cardiovascular Translational Research·Sabu Thomas, Edward O McFalls
Feb 1, 2005·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·John M Canty, James A Fallavollita
Jan 24, 2009·Nature Reviews. Drug Discovery·Peter FraislPeter Carmeliet
Dec 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dalit MayEli Keshet
Oct 23, 2010·European Heart Journal·Nina GhoshPaolo G Camici
Aug 5, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Nadia HedhliChristophe Depre
Feb 15, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Li ChenChristophe Depre
Oct 11, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Henry ChangSubha V Raman
Sep 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lin YanStephen F Vatner
Apr 17, 2009·Canadian Journal of Physiology and Pharmacology·Jan SlezakPawan Singal
Jan 21, 2014·FEBS Letters·Magda Dubińska-MagieraMałgorzata Daczewska
Jun 20, 2012·The International Journal of Biochemistry & Cell Biology·Elisabeth S ChristiansIvor J Benjamin
Apr 24, 2012·The International Journal of Biochemistry & Cell Biology·Julie AcunzoPalma Rocchi
Dec 1, 2009·Journal of Cardiac Failure·Vincenzo LionettiAlessandro Pingitore
Jun 30, 2007·Annals of the New York Academy of Sciences·Deepak SrivastavaIldiko Bock-Marquette
Apr 21, 2007·Cardiovascular Drug Reviews·Ilan J DananChristophe Depre
Feb 9, 2006·European Journal of Heart Failure·Korff T KrauseKarl-Heinz Kuck
Jan 22, 2014·Journal of Cellular and Molecular Medicine·Vincenzo LionettiAngela Pucci
Jul 26, 2005·Trends in Cardiovascular Medicine·Christophe Depre, Stephen F Vatner
Sep 19, 2012·Cardiology Research and Practice·Adel Shabana, Ayman El-Menyar
May 8, 2015·Journal of Cardiovascular Translational Research·Robert W ColbertEdward O McFalls
Jan 24, 2015·Basic Research in Cardiology·Lin YanStephen F Vatner
Feb 21, 2006·Journal of the American College of Cardiology·Hiroshi HasegawaIssei Komuro
Jun 29, 2010·Journal of the American College of Cardiology·Katrina Go YamazakiFrancisco J Villarreal
Nov 22, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Gerhard-Paul DillerJamil Mayet
Mar 1, 2011·Journal of Molecular and Cellular Cardiology·Manuel MayrEli Keshet
Mar 9, 2011·Journal of Molecular and Cellular Cardiology·Gerd HeuschRainer Schulz
Nov 7, 2012·Journal of Molecular and Cellular Cardiology·Claudio BravoLin Yan

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