Programmable Mechanical Properties from a Worm Jaw-Derived Biopolymer through Hierarchical Ion Exposure

ACS Applied Materials & Interfaces
Maneesh K GuptaRajesh R Naik

Abstract

Mechanisms of biomaterial sclerotization in natural systems promise new insights into how the mechanical properties of engineered materials may be dynamically modulated. One such example involves the proteinaceous jaw of the marine sandworm, Nereis virens. Previously, the mechanical properties of the N. virens jaw were shown to be modulated by Zn binding, a property that was proposed to be enabled by the presence of the histidine-rich jaw protein, Nvjp-1. Here we demonstrate the creation of Nvjp-1-based hydrogels and show that progressive sclerotization of these hydrogels can be accomplished with hierarchical exposure to metal cations and anions. Divalent Zn cations are capable of reversibly sclerotizing the hydrogels through the formation of coordinate cross-links, an effect that is shown to be remarkably specific for Zn. Additionally, the degree of Zn-induced sclerotization is strongly influenced by the identity of the anion present in the hydrogel. Thus, the viscoelastic properties of Nvjp-1 hydrogels can be modulated through programmed, hierarchical exposure to specific cations and anions present in the sclerotizing salts. These observations have resulted in new hydrogel capabilities, such as the creation of anion-controlle...Continue Reading

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Citations

Aug 1, 2019·Biomaterials Science·Anastasiia KashirinaJinsong Leng
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Alina Kirillova, Leonid Ionov
Feb 11, 2020·Frontiers in Chemistry·Sanaz FarajollahiRajesh R Naik
Mar 10, 2021·Biomacromolecules·Yao WangJin Kim Montclare

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