Programmatic impact of QuantiFERON-TB Gold In-Tube implementation on latent tuberculosis diagnosis and treatment in a public health clinic.

PloS One
Maunank ShahSusan Dorman

Abstract

QuantiFERON-TB Gold In-Tube (QFT-GIT) is considered an alternative to the tuberculin skin test (TST) for the diagnosis of tuberculosis (TB) infection, but the programmatic impact of QFT-GIT implementation is largely unknown. In March, 2010, the Baltimore City Health Department (BCHD) introduced routine QFT-GIT testing for individuals referred to the TB program for suspected latent TB infection (LTBI). Retrospective study comparing LTBI diagnosis and treatment during the 13 months before and after QFT-GIT implementation at the BCHD TB clinic. 607 and 750 individuals were referred by community-providers for suspected LTBI in the pre- and post-QFT-GIT periods, respectively. Most individuals in the pre- and post-QFT-GIT periods were referred on the basis of a positive TST (597/607 [98%] vs. 690/750 [92%], respectively) and were foreign-born (363/607[59%] vs. 507/750[68%], respectively). BCHD performed QFT-GIT testing for 375/543 (69%) eligible individuals in the post-QFT-GIT period, of which 185 (49%) were positive, 178 (47%) were negative, 1 (0.25%) was indeterminate, and 11 (3%) did not yield results. Concordance of QFT-GIT with TST was low (183/352[52%]). Foreign-born individuals had higher proportions of QFT-GIT positivity (57%...Continue Reading

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Citations

Jul 6, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shamim IslamJulie Higashi
Jul 6, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sharon E McMullenAlexandra C Sheller
Mar 30, 2016·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Maria KoufopoulouLavanya Diwakar
Nov 24, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Z AhmadinejadA Jafarian
May 21, 2016·Journal of the Pediatric Infectious Diseases Society·Jennifer A GrinsdaleJulie M Higashi
May 18, 2016·BMC Infectious Diseases·Andreas SandgrenMarieke J van der Werf
Apr 2, 2013·PloS One·Christiaan MulderFrank van Leth
Feb 13, 2016·American Journal of Respiratory and Critical Care Medicine·James D MancusoTzu-Cheg Kao
Oct 31, 2015·Journal of the International Association of Providers of AIDS Care·Hamideh KhazraiyanAhmad Soltani

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Methods Mentioned

BETA
ELISA
blood

Software Mentioned

QFT
STATA
GIT

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