Programmed Aging of Mammals: Proof of Concept and Prospects of Biochemical Approaches for Anti-aging Therapy

Biochemistry. Biokhimii︠a︡
M V Skulachev, V P Skulachev

Abstract

(i) In 2015-2017 we compared possible reasons for longevity of two mammalian highly social species, i.e. naked mole rats and humans. We proposed that in both cases longevity is a result of neoteny, prolongation of youth by deceleration of late ontogeny (Skulachev, V. P. (2015) Abst. 11th Conf. on Mitochondrial Physiology (MiP2015), Lucni Bouda, Czech Republic, pp. 64-66; Skulachev, V. P., Holtze, S., Vyssokikh, M. Y., Bakeeva, L. E., Skulachev, M. V., Markov, A. V., Hildebrandt, T. B., and Sadovnichii, V. A. (2017) Physiol. Rev., 97, 699-720). Both naked mole rats and humans strongly decreased the pressure of natural selection, although in two different manners. Naked mole rats preferred an "aristocratic" pathway when reproduction (and, hence, involvement in evolution) is monopolized by the queen and her several husbands. Huge number of subordinates who have no right to take part in reproduction and hence in evolution serves the small queen's family. Humans used an alternative, "democratic" pathway, namely technical progress facilitating adaptation to the changing environmental conditions. This pathway is open to all humankind. (ii) As a result, aging as a mechanism increasing evolvability by means of facilitation of natural se...Continue Reading

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Citations

Apr 16, 2019·Rejuvenation Research·Si-Jun ZhaoXue-Mei Qin
May 30, 2019·Biology·Andrei SurguchovAlexei A Surguchev
Mar 1, 2018·Biochemistry. Biokhimii︠a︡·V N ManskikhA I Nikiforova
Apr 2, 2020·Aging·Vladimir P SkulachevVictor A Sadovnichii
Dec 13, 2019·Oxidative Medicine and Cellular Longevity·Konstantin G LyamzaevBoris V Chernyak
Feb 7, 2020·Physiology·Rochelle BuffensteinHolly M Brown-Borg
Nov 16, 2019·BioData Mining·Lev I RubanovVassily A Lyubetsky
Jun 27, 2020·Biochemistry. Biokhimii︠a︡·S S Sokolov, F F Severin
Mar 11, 2020·Proceedings of the National Academy of Sciences of the United States of America·Mikhail Y VyssokikhVladimir P Skulachev
Aug 3, 2019·European Journal of Medicinal Chemistry·Lucia BiasuttoMario Zoratti
Feb 24, 2021·The Ocular Surface·Jeremias G Galletti, Cintia S de Paiva

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