Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease

FEBS Letters
Jiro FukaeNobutaka Hattori

Abstract

Mutations in parkin gene are responsible for autosomal recessive Parkinson's disease (ARPD) and its loss-of-function is assumed to affect parkin ubiquitin ligase activity. Accumulation of its substrate may induce dopaminergic neurodegeneration in the substantia nigra (SN) of ARPD. Here, we show that parkin interacts with programmed cell death-2 isoform 1 (PDCD2-1) and promotes its ubiquitination. Furthermore, accumulation of PDCD2-1 was found in the SN of ARPD as well as in sporadic PD, suggesting that common failure of the ubiquitin-proteasome system is associated with neuronal death in both ARPD and sporadic PD.

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Citations

Feb 5, 2010·Apoptosis : an International Journal on Programmed Cell Death·Hansruedi Büeler
Apr 25, 2012·Cellular and Molecular Life Sciences : CMLS·Helen Walden, R Julio Martinez-Torres
Aug 13, 2013·Expert Opinion on Therapeutic Targets·Shin-Ichiro KuboNobutaka Hattori
Jan 23, 2016·Frontiers in Aging Neuroscience·Cheng-Wu ZhangKah-Leong Lim
Mar 11, 2016·BMC Medical Genomics·Maykel Cruz-MonteagudoEduardo Tejera
Jun 14, 2013·Cancer Biology & Therapy·Nora BarbozaDale G Schaar
Jun 15, 2016·PloS One·Tiago Silva ValenteMateus José Rodrigues Paranhos da Costa
May 22, 2019·PloS One·Kyung-Ran ParkJin Tae Hong
Jan 24, 2018·Nature Reviews. Molecular Cell Biology·J Wade HarperJin-Mi Heo
Apr 21, 2012·Protein Science : a Publication of the Protein Society·Steven A BeasleyGary S Shaw
Jul 7, 2016·Journal of Neurochemistry·Damien ToulorgeRodolphe Hajj
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Dec 25, 2009·Rinshō shinkeigaku = Clinical neurology·Nobutaka Hattori
Aug 26, 2014·Biology Open·Celine J GranierArnold B Rabson

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