PMID: 9446329Jan 31, 1998Paper

Programmed cell death (apoptosis): molecular mechanisms and the role in biology and medicine

Voprosy medit︠s︡inskoĭ khimii
K P Khanson

Abstract

Over the recent years studies of the cell death (CD) were progressing with an outstanding speed. CD is found to play a key role in proliferation, differentiation, embryogenesis, morphogenesis and homeostatic processes. CD abnormalities significantly contribute into numerous human diseases as cancer, AIDS, degenerative pathologies of nervous system and developmental abnormalities. The elucidation of CD mechanisms may promote our understanding of pathogenesis of various diseases and facilitate search for their treatment.

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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