Programmed cell death in vegetative development: apoptosis during the colonial life cycle of the ascidian Botryllus schlosseri

Tissue & Cell
Stefano TiozzoGiovanna Zaniolo

Abstract

Programmed cell death (PCD) by apoptosis is a physiological mechanism by which cells are eliminated during embryonic and post-embryonic stages of animal life cycle. During asexual reproduction, the zooids of colonial ascidians originate from an assorted cell population instead of a single zygote, so that we assume that regulation of the equilibrium among proliferation, differentiation and cell death may follow different pathways in comparison to the embryonic development. Here we investigate the presence of apoptotic events throughout the blastogenetic life cycle of the colonial ascidian Botryllus schlosseri, by means of terminal deoxynucleotidyl transferase dUTP Nick End Labeling (TUNEL) coupled with histochemical and electron microscopy techniques. The occurrence of low levels of morphogenetic cell death suggests that, in contrast to what happens during sexual development (embryogenesis and metamorphosis), apoptosis does not play a pivotal role during asexual propagation in botryllid ascidian. Nevertheless, PCD emerges as a key force to regulate homeostasis in adult zooids and to shape and modulate the growth of the whole colony.

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Citations

Mar 5, 2009·In Vitro Cellular & Developmental Biology. Animal·Claudette RabinowitzBaruch Rinkevich
Jan 30, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Fabio GaspariniGiovanna Zaniolo
Dec 28, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L ManniL Ballarin
Apr 4, 2016·BMC Genomics·Davide CampagnaLoriano Ballarin
Nov 24, 2012·Developmental Biology·Robert J LauzonStefano Tiozzo
Feb 1, 2008·Developmental Biology·Stefano TiozzoAnthony W De Tomaso
Apr 24, 2016·Developmental and Comparative Immunology·Nicola FranchiLoriano Ballarin
Jun 7, 2018·Integrative and Comparative Biology·Lucia ManniFabio Gasparini
Jun 27, 2017·Frontiers in Immunology·Nicola Franchi, Loriano Ballarin
Feb 15, 2019·Developmental Biology·Delany RodriguezAnthony W De Tomaso
Oct 8, 2021·BMC Molecular and Cell Biology·Gabriel KrasovecJean-Philippe Chambon

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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