Programmed Cell Death Ligand 1 Expression Is an Independent Prognostic Factor in Colorectal Cancer

Anticancer Research
Tumenjin EnkhbatMitsuo Shimada

Abstract

Programmed cell death protein 1 (PD-1)/ programmed cell death ligand 1(PD-L1) axis is associated with immune tolerance via inhibition of T cell activation. The aim of this study was to clarify the significance of PD-1 and PD-L1 expressions and analyze the relationships between PD-1, PD-L1, transforming growth factor-β (TGF-β) and Forkhead box P3 (Foxp3) expressions in colorectal cancer (CRC). A total of 116 patients who underwent curative colectomy for stage II/III CRC were included in the study. PD-1, PD-L1, TGF-β, and Foxp3 expressions were examined by immunohistochemistry and related to prognostic factors by Kaplan-Meier. PD-1 expression was correlated with PD-L1, TGF-β, and Foxp3 expressions. Overall survival rates were significantly poorer in the PD-1 and PD-L1-positive groups. Multivariate analysis showed that PD-L1-positive is an independent risk factor. Disease-free survival (DFS) was tended in the PD-L1-positive group. The group with double-positive expression had significantly poorer prognosis. PD-1 and PD-L1 expressions were associated with a poor prognosis and correlated with TGF-β and Foxp3 expressions in patients with CRC.

Citations

Nov 6, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·X NiJ Suo
Sep 11, 2020·International Journal of Colorectal Disease·Shuxia WangJihong Hu
Oct 13, 2020·PloS One·Chie TakasuMitsuo Shimada
Jan 9, 2021·Pathology, Research and Practice·Yibin ZhaoQi Wang
Nov 20, 2021·PloS One·Chie TakasuMitsuo Shimada

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