Programmed cell death of dendritic cells in immune regulation.

Immunological Reviews
Min Chen, Jin Wang

Abstract

Programmed cell death is essential for the maintenance of lymphocyte homeostasis and immune tolerance. Dendritic cells (DCs), the most efficient antigen-presenting cells, represent a small cell population in the immune system. However, DCs play major roles in the regulation of both innate and adaptive immune responses. Programmed cell death in DCs is essential for regulating DC homeostasis and consequently, the scope of immune responses. Interestingly, different DC subsets show varied turnover rates in vivo. The conventional DCs are relatively short-lived in most lymphoid organs, while plasmacytoid DCs are long-lived cells. Mitochondrion-dependent programmed cell death plays an important role in regulating spontaneous DC turnover. Antigen-specific T cells are also capable of killing DCs, thereby providing a mechanism for negative feedback regulation of immune responses. It has been shown that a surplus of DCs due to defects in programmed cell death leads to overactivation of lymphocytes and the onset of autoimmunity. Studying programmed cell death in DCs will shed light on the roles for DC turnover in the regulation of the duration and magnitude of immune responses in vivo and in the maintenance of immune tolerance.

References

Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K J Gollob, E Palmer
Jan 1, 1991·Annual Review of Immunology·R M Steinman
Feb 1, 1974·The Journal of Experimental Medicine·R M Steinman, Z A Cohn
Jan 1, 1995·Immunology Today·S Nagata, T Suda
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M AdachiS Nagata
Apr 1, 1994·The Journal of Experimental Medicine·D F Tough, J Sprent
Oct 1, 1993·Immunological Reviews·H von BoehmerP Kisielow
Jan 28, 1994·Cell·G J Nossal
Sep 1, 1996·The Journal of Clinical Investigation·J WuJ D Mountz
Mar 1, 1997·International Immunology·P BjörckL Flores-Romo
Apr 1, 1997·Current Opinion in Immunology·P Marrack, J Kappler
Jun 16, 1997·The Journal of Experimental Medicine·E IngulliM K Jenkins
Sep 18, 1997·The Journal of Experimental Medicine·I Fugier-VivierC Rabourdin-Combe
Feb 17, 1998·European Journal of Immunology·T A KoppiM R Alderson
Apr 1, 1998·Nature·J Banchereau, R M Steinman
May 20, 1998·Immunity·C M WalshS M Hedrick
Oct 23, 1998·The Journal of Experimental Medicine·B LudewigR M Zinkernagel
Jun 8, 1999·Annual Review of Immunology·D WallachM P Boldin
Jun 8, 1999·Annual Review of Immunology·J C Rathmell, C B Thompson
Jun 22, 1999·Leukemia Research·M A RoskrowM K Brenner
Aug 13, 1999·Genes & Development·A GrossS J Korsmeyer
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·C BaiC T Caskey
Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·I F HermansF Ronchese

❮ Previous
Next ❯

Citations

Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yanyan WangHongbo Chi
Nov 16, 2011·The Journal of Experimental Medicine·Melissa SwieckiMarco Colonna
Dec 2, 2011·Mediators of Inflammation·Rosanna Di PaolaSalvatore Cuzzocrea
Nov 26, 2010·BMC Complementary and Alternative Medicine·Irene PaternitiSalvatore Cuzzocrea
Jun 23, 2012·PloS One·Geng YangXiaobo Zhang
Nov 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yanyan WangHongbo Chi
Jan 1, 2014·Vaccines·Hadeel KhalloufAngelika B Riemer
Mar 1, 2012·Human Immunology·Chiara GaspariniGiorgio Zauli
Mar 31, 2011·Journal of Cellular Physiology·Antonella NaldiniFabio Carraro
Jul 20, 2010·Immunological Reviews·Philippa MarrackMegan K L MacLeod
Feb 6, 2015·European Journal of Immunology·Akhila BalachanderPaola Ricciardi-Castagnoli
Jun 20, 2015·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Mohit SehgalPooja Jain
May 6, 2016·Frontiers in Pharmacology·Anja SchwiebsHeinfried H Radeke
Aug 6, 2016·Cellular and Molecular Life Sciences : CMLS·Michael TangMark S Cattral
May 21, 2016·European Journal of Immunology·Sophie UzureauEtienne Pays
Jan 13, 2017·Cell Death & Disease·Yuechen LuoXiaoming Feng
Sep 27, 2019·Scientific Reports·Nichole TackettRandal K Gregg
Oct 28, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Min ChenJin Wang
Dec 12, 2019·Frontiers in Immunology·Laura Stentoft CarstensenMorten Hansen
Aug 7, 2019·International Urology and Nephrology·Kevin J ZhangJason M Hafron
Jan 8, 2021·Journal for Immunotherapy of Cancer·Anastasia ProkopiPatrizia Stoitzner
Aug 24, 2021·Current Opinion in Immunology·Margaret M McDanielChandrashekhar Pasare

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis